Evidence map›Paper›PMID 28507805›Full record

ArticleOncoimmunology

Generation and functional characterization of MDSC-like cells.

Annkristin Heine, Stefanie Andrea Erika Held, Jonas Schulte-Schrepping, Julia Friederike Andrea Wolff, Kathrin Klee, Thomas Ulas, Niklas Arndt Schmacke, Solveig Nora Daecke, Kati Riethausen, Joachim L Schultze and 1 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
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  8. Myeloid-Derived Suppressor Cells and CD68Journal of immunology research · 2022
    Article
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  11. Article
  12. Article
  13. Review
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  18. Article
  19. The Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia.Frontiers in cell and developmental biology · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Annkristin HeineMedical Clinic III for Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany.
Stefanie Andrea Erika HeldMedical Clinic III for Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany.
Jonas Schulte-SchreppingGenomics and Immunoregulation, LIMES-Institute, University of Bonn, Bonn, Germany.
Julia Friederike Andrea WolffMedical Clinic III for Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany.
Kathrin KleeGenomics and Immunoregulation, LIMES-Institute, University of Bonn, Bonn, Germany.
Thomas UlasGenomics and Immunoregulation, LIMES-Institute, University of Bonn, Bonn, Germany.
Niklas Arndt SchmackeGenomics and Immunoregulation, LIMES-Institute, University of Bonn, Bonn, Germany.
Solveig Nora DaeckeMedical Clinic III for Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany.
Kati RiethausenMedical Clinic III for Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany.
Joachim L SchultzeGenomics and Immunoregulation, LIMES-Institute, University of Bonn, Bonn, Germany.
Peter BrossartMedical Clinic III for Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany.
University Hospital Bonn · DEUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myeloid-derived suppressor cells (MDSC) are critical in regulating immune responses by suppressing antigen presenting cells (APC) and T cells. We previously observed that incubation of peripheral blood monocytes with interleukin (IL)-10 during their differentiation to monocyte-derived dendritic cells (moDCs) results in the generation of an APC population with a CD14

Indexed as

APCGITRIL-10immunosuppressionMDSCosteoactivinPD-1PD-L1syndecan-4

Identifiers

PMID28507805
PMCPMC5414884
OpenAlexW2590261550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.