ArticleBiomarker research2017
Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer.
Article in Biomarker research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- CTC cluster in breast cancer: synergetic metastasis promotion mechanism and transformation path from platelet cloaking to leukocyte escort.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
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- Unique Cohorts of Salivary Gland Cancer Cells as anJournal of maxillofacial and oral surgery · 2024Article
- Colorectal cancer and dormant metastases: Put to sleep or destroy?World journal of gastrointestinal oncology · 2024Article
- Circulating tumor cells clusters and their role in Breast cancer metastasis; a review of literature.Discover oncology · 2024Review
- Downregulation of γ-Catenin by miR-195-5p Inhibits Colon Cancer Progression, Regulating Desmosome Function.International journal of molecular sciences · 2023Article
- Androgen dihydrotestosterone promotes bladder cancer cell proliferation and invasion via EPPK1-mediated MAPK/JUP signalling.Cell death & disease · 2023Article
- ICAT promotes colorectal cancer metastasis via binding to JUP and activating the NF-κB signaling pathway.Journal of clinical laboratory analysis · 2022Article
- Novel approaches in search for biomarkers of cholangiocarcinoma.World journal of gastroenterology · 2022Review
- Dormancy: There and Back Again.Molecular biology · 2022Article
- Effects of differential distributed-JUP on the malignancy of gastric cancer.Journal of advanced research · 2021Article
- Mitotic arrest affects clustering of tumor cells.Cell division · 2021Article
- Correlation Between Circulating Tumor Cell DNA Genomic Alterations and Mesenchymal CTCs or CTC-Associated White Blood Cell Clusters in Hepatocellular Carcinoma.Frontiers in oncology · 2021Article
- Tumor Hypoxia and Circulating Tumor Cells.International journal of molecular sciences · 2020Review
- Circulating Tumor Cell Clusters: United We Stand Divided We Fall.International journal of molecular sciences · 2020Review
- Microenvironmental Determinants of Breast Cancer Metastasis: Focus on the Crucial Interplay Between Estrogen and Insulin/Insulin-Like Growth Factor Signaling.Frontiers in cell and developmental biology · 2020Review
- A CTC-Cluster-Specific Signature Derived from OMICS Analysis of Patient-Derived Xenograft Tumors Predicts Outcomes in Basal-Like Breast Cancer.Journal of clinical medicine · 2019Article
- The prognostic significance of circulating tumor cells in head and neck and non-small-cell lung cancer.Cancer medicine · 2018Article
- Novel evaluation scale for QOL (QOL-ACD-BP) in preoperative chemotherapy for breast cancer.Journal of cancer research and clinical oncology · 2018Article
- Organ-specific metastasis of breast cancer: molecular and cellular mechanisms underlying lung metastasis.Cellular oncology (Dordrecht, Netherlands) · 2018Review
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCirculating tumor cells (CTCs) are linked to metastatic relapse and are regarded as a prognostic marker for human cancer. High expression of plakoglobin, a cell adhesion protein, within the primary tumor is positively associated with CTC clusters in breast cancer. In this study, we investigated the correlation between plakoglobin expression and survival of breast cancer.
methodsWe evaluated 121 breast cancer patients treated with neoadjuvant chemotherapy. Expression of plakoglobin was identified by immunohistochemical staining in the cell membrane. We also examined the relation between the expression of plakoglobin and E-cadherin, an epithelial-mesenchymal transition (EMT) marker.
resultsPatients with high plakoglobin expression had significantly worse distant-metastasis-free survival (DMFS) (
conclusionsPlakoglobin expression is an independent prognostic factor in patients with breast cancer, particularly for DMFS, and this is related to EMT.
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