ArticleTherapeutic advances in neurological disorders2017
Health-related quality of life outcomes from botulinum toxin treatment in hemifacial spasm.
Article in Therapeutic advances in neurological disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Efficacy and safety of botulinum neurotoxin in the treatment of hemifacial spasms: a systematic review and meta-analysis.BMC neurology · 2024Pooled it
- Assessment of quality of life in patients with cervical dystonia and hemifacial spasm after botulinum toxin injections.Acta neurologica Belgica · 2025Article
- Minimal important changes of HFS-30 and HFS-7 questionnaires for patients with hemifacial spasm.Clinical parkinsonism & related disorders · 2025Article
- Validation of a new hemifacial spasm grading questionnaire (HFS score) assessing clinical and quality of life parameters.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Observational
- Long-term treatment of blepharospasm with botulinum toxin A: a service-based study over a 16-year follow-up in southern China.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Validation of the Hemifacial Spasm Grading Scale: a clinical tool for hemifacial spasm.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Botulinumtoxin Improves both Generic and Disease-Specific Quality of Life in Cervical Dystonia.Frontiers in neurology · 2017Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough botulinum neurotoxin (BoNT) injections may alleviate involuntary muscle contractions in hemifacial spasm substantially, it is less clear whether the motor effect would translate into improvements of health-related quality of life (HR-QoL).
methodsIn this open-label clinical observational study, we characterized outcomes on HR-QoL in terms of the EuroQol (EQ-5D-5L) from BoNT in a prospective cohort of patients with hemifacial spasm (
resultsPatients showed improved HR-QoL on the EQ-VAS (visual analogue scale) at timepoint2 compared with timepoint1. Moreover, we identified, that impairments in HR-QoL at timepoint1 correlated with life satisfaction and depressive symptoms, respectively. However, these associated variables did not predict the therapeutic effect. Instead, EQ-VAS at timepoint1 accounted for 34.5% of the variance of EQ-VAS improvement expressed as the difference between timepoint2 and timepoint1.
conclusionOur study supports HR-QoL improvements in hemifacial spasm and the value of generic HR-QoL measures to estimate therapeutic outcome. However, the findings should be considered descriptive, and future high quality trials are needed for confirmatory purposes in order to refine treatment referral in hemifacial spasm with respect to QoL.
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