ReviewFrontiers in aging neuroscience2017
Body-Brain Connections: The Effects of Obesity and Behavioral Interventions on Neurocognitive Aging.
Review in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Extensive Review of Persuasive System Design Categories and Principles: Behavioral Obesity Interventions.Journal of medical systems · 2020Pooled it
- The Effects of a 12-Month Weight Loss Intervention on Cognitive Outcomes in Adults with Overweight and Obesity.Nutrients · 2020Trial
- Sexual Dimorphism in the Relationship between Body Composition and Insulin Resistance in Older Adults.Current developments in nutrition · 2026Article
- Association between cumulative average BMI and cognitive decline: a 24-year cohort study.Journal of neurology · 2026Article
- Elucidating neural molecular mechanisms underlying metabolic disorders-induced neuropsychiatric disorders in mice on prolonged high fructose diet.Metabolic brain disease · 2025Article
- Refined carbohydrates and the overfat pandemic: implications for brain health and public health policy.Frontiers in public health · 2025Review
- White adipose tissue distribution and amount are associated with increased white matter connectivity.Human brain mapping · 2024Article
- Neural ageing and synaptic plasticity: prioritizing brain health in healthy longevity.Frontiers in aging neuroscience · 2024Review
- The Role of Oxidative Stress and Inflammation in Obesity and Its Impact on Cognitive Impairments-A Narrative Review.Antioxidants (Basel, Switzerland) · 2023Review
- The Utility of High Intensity Interval Training to Improve Cognitive Aging in Heart Disease Patients.International journal of environmental research and public health · 2022Review
- The Interplay between Ghrelin and Microglia in Neuroinflammation: Implications for Obesity and Neurodegenerative Diseases.International journal of molecular sciences · 2022Review
- Metabolism and memory: α-synuclein level in children with obesity and children with type 1 diabetes; relation to glucotoxicity, lipotoxicity and executive functions.International journal of obesity (2005) · 2022Article
- Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health.Nature communications · 2022Article
- Evidence of association between obesity and lower cerebral myelin content in cognitively unimpaired adults.International journal of obesity (2005) · 2021Article
- PART 3 Bypassing TBI: Metabolic Surgery and the Link Between Obesity and Traumatic Brain Injury-a Review.Obesity surgery · 2021Review
- Placental programming, perinatal inflammation, and neurodevelopment impairment among those born extremely preterm.Pediatric research · 2021Review
- Bypassing TBI: Metabolic Surgery and the Link between Obesity and Traumatic Brain Injury-a Review.Obesity surgery · 2020Review
- Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Project.Journal of clinical medicine · 2020Article
- Role of Sirtuins in Modulating Neurodegeneration of the Enteric Nervous System and Central Nervous System.Frontiers in neuroscience · 2020Review
- Impulsivity and body fat accumulation are linked to cortical and subcortical brain volumes among adolescents and adults.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Obesity is a growing public health problem in the United States, particularly in middle-aged and older adults. Although the key factors leading to a population increase in body weight are still under investigation, there is evidence that certain behavioral interventions can mitigate the negative cognitive and brain ("neurocognitive") health consequences of obesity. The two primary behaviors most often targeted for weight loss are caloric intake and physical activity. These behaviors might have independent, as well as overlapping/synergistic effects on neurocognitive health. To date obesity is often described independently from behavioral interventions in regards to neurocognitive outcomes, yet there is conceptual and mechanistic overlap between these constructs. This review summarizes evidence linking obesity and modifiable behaviors, such as physical activity and diet, with brain morphology (e.g., gray and white matter volume and integrity), brain function (e.g., functional activation and connectivity), and cognitive function across the adult lifespan. In particular, we review evidence bearing on the following question:
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.