Evidence map›Paper›PMID 28507467›Full record

ArticleEXCLI journal2017

Preparation and characterization of beta-glucan particles containing a payload of nanoembedded rifabutin for enhanced targeted delivery to macrophages.

Tarun K Upadhyay, Nida Fatima, Deepak Sharma, V Saravanakumar, Rolee Sharma

Open access · greenAbstract read
In one paragraph

Article in EXCLI journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
11.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
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  8. Synthesis of immunomodulatory biomimetic lipid polymer hybrid nanoparticles and application of zebrafish larvae in immunomodulation screening.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2025
    Article
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  15. Characterization of β-glucan obtained fromOpen veterinary journal · 2024
    Article
  16. Review
  17. Review
  18. Preparation ofACS applied bio materials · 2023
    Article
  19. Tools to Alleviate the Drug Resistance inMolecules (Basel, Switzerland) · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tarun K UpadhyayDepartment of Biosciences, Integral University, Lucknow, 226026, India.
Nida FatimaDepartment of Biosciences, Integral University, Lucknow, 226026, India.
Deepak SharmaPharmaceutics Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India.
V SaravanakumarPharmaceutics Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India.
Rolee SharmaDepartment of Biosciences, Integral University, Lucknow, 226026, India.
Central Drug Research Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

β-glucan particles (GP) are polymeric carbohydrates, mainly found as components of cell wall fungi, yeast, bacteria and also in cereals such as barley and oat, and have been recently shown to have application in macrophage-targeted drug delivery. The aim of this study was to prepare and characterize GP containing a large payload of Rifabutin (RB), an anti-tuberculosis drug effective against MDR-TB at lower MIC than Rifampicin. GP were prepared from yeast cells by acidic and alkaline extraction were either spray dried or lyophilized, prior to RB loading and alginate sealing. The FTIR and

Indexed as

glucan particlesmacrophagephagocytosisrifabutinspray dryingtargeted drug delivery

Identifiers

PMID28507467
PMCPMC5427468
OpenAlexW2745788007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.