Evidence map›Paper›PMID 28507434›Full record

ArticleInternational journal of nanomedicine2017

Enhanced oral bioavailability of valsartan using a polymer-based supersaturable self-microemulsifying drug delivery system.

Dong Woo Yeom, Bo Ram Chae, Ho Yong Son, Jin Han Kim, Jun Soo Chae, Seh Hyon Song, Dongho Oh, Young Wook Choi

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 62 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dong Woo YeomCollege of Pharmacy, Chung-Ang University, Seoul.
Bo Ram ChaeDaewon Pharm. Co., Ltd, Seoul, Republic of Korea.
Ho Yong SonCollege of Pharmacy, Chung-Ang University, Seoul.
Jin Han KimCollege of Pharmacy, Chung-Ang University, Seoul.
Jun Soo ChaeCollege of Pharmacy, Chung-Ang University, Seoul.
Seh Hyon SongDaewon Pharm. Co., Ltd, Seoul, Republic of Korea.
Dongho OhDaewon Pharm. Co., Ltd, Seoul, Republic of Korea.
Young Wook ChoiCollege of Pharmacy, Chung-Ang University, Seoul.
Chung-Ang University · KRDaewon Pharm (South Korea) · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel, supersaturable self-microemulsifying drug delivery system (S-SMEDDS) was successfully formulated to enhance the dissolution and oral absorption of valsartan (VST), a poorly water-soluble drug, while reducing the total quantity for administration. Poloxamer 407 is a selectable, supersaturating agent for VST-containing SMEDDS composed of 10% Capmul

Indexed as

Administration, OralAnimalsBiological AvailabilityCaprylatesDrug Delivery SystemsEmulsionsEthylene GlycolsGlyceridesMalePolymersPolysorbatesRats, Sprague-DawleySolubilityValsartanCaprylatescarbitolEmulsionsEthylene GlycolsGlyceridesmonooctanoinPolymersPolysorbatesValsartanbio-availabilityfactorial designoptimizationSMEDDSsupersaturationvalsartan

Identifiers

PMID28507434
PMCPMC5428796
OpenAlexW2612534502

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.