ArticleScientific reports2017
Increased leukotoxin production: Characterization of 100 base pairs within the 530 base pair leukotoxin promoter region of Aggregatibacter actinomycetemcomitans.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Chrysin and Luteolin from Moroccan Propolis to Prevent Aggressive Periodontitis Caused byPharmaceuticals (Basel, Switzerland) · 2026Article
- Review
- Leukotoxin A Production and Release by JP2 and Non-JP2 GenotypePathogens (Basel, Switzerland) · 2024Article
- Prevalence of the oral pathogenFrontiers in cellular and infection microbiology · 2024Article
- The Highly Leukotoxic JP2 Genotype ofPathogens (Basel, Switzerland) · 2022Article
- Review
- Etiology of aggressive periodontitis in individuals of African descent.The Japanese dental science review · 2021Review
- Characterization ofVaccines · 2020Article
- Aggregatibacter, A Low Abundance Pathobiont That Influences Biogeography, Microbial Dysbiosis, and Host Defense Capabilities in Periodontitis: The History of A Bug, And Localization of Disease.Pathogens (Basel, Switzerland) · 2020Review
- Review
- Virulence and Pathogenicity Properties ofPathogens (Basel, Switzerland) · 2019Review
- Differential Cell Lysis Among Periodontal Strains of JP2 and Non-JP2 Genotype ofPathogens (Basel, Switzerland) · 2019Article
- Article
- Review
- Rheumatoid Arthritis-Associated Mechanisms ofJournal of clinical medicine · 2019Review
- Review
- Rheumatoid Arthritis-Associated Autoimmunity Due toFrontiers in immunology · 2018Article
- The chronicles of green complex bacteria.Journal of oral and maxillofacial pathology : JOMFPReview
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Aggregatibacter actinomycetemcomitans leukotoxin (LtxA) is a major virulence factor that kills leukocytes permitting it's escape from host immune surveillance. A. actinomycetemcomitans strains can produce high or low levels of toxin. Genetic differences reside in the "so called JP2" ltxA promoter region. These hyper-leukotoxin producing strains with the 530 bp deletion have been studied in detail. However, regions contained within the 530 bp deletion that could be responsible for modulation of leukotoxin production have not been defined. Here, we report, for the first time, on regions within the 530 bp that are responsible for high-levels of ltxA expression. We constructed a deletion of 530 bps in a primate isolate of A. actinomycetemcomitans, which produced leukotoxin equivalent to the JP2 strain. We then constructed sequential deletions in regions that span the 530 bps. Results indicated that expression of the ltxA transcript was reduced by a potential transcriptional terminator in promoter region 298 to 397 with a ΔG = -7.9 kcal/mol. We also confirmed previous findings that transcriptional fusion between the orfX region and ltxC increased ltxA expression. In conclusion, we constructed a hyper-leukotoxin producing A. actinomycetemcomitans strain and identified a terminator located in the promoter region extending from 298-397 that alters ltxA expression.
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