ArticleScientific reports2017
BNIP3L promotes cardiac fibrosis in cardiac fibroblasts through [Ca
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
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- Sympathetic overactivation and catecholamine toxicity: mechanisms and therapeutic strategies for neurogenic heart injury following acute ischemic stroke.Frontiers in cardiovascular medicine · 2025Review
- Dynamic and static biomechanical traits of cardiac fibrosis.Frontiers in bioengineering and biotechnology · 2022Review
- Serum coding and non-coding RNAs as biomarkers of NAFLD and fibrosis severity.Liver international : official journal of the International Association for the Study of the Liver · 2019Article
- The prognostic value of ADRA1 subfamily genes in gastric carcinoma.Oncology letters · 2019Article
- Calcium‑sensing receptor promotes high glucose‑induced myocardial fibrosis via upregulation of the TGF‑β1/Smads pathway in cardiac fibroblasts.Molecular medicine reports · 2019Article
- Electrical Stimulation Activates Fibroblasts through the Elevation of Intracellular Free CaBioMed research international · 2019Article
- Role of cytokines and inflammation in heart function during health and disease.Heart failure reviews · 2018Review
- Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis.Molecular medicine reports · 2018Article
- Nogo-C regulates post myocardial infarction fibrosis through the interaction with ER CaCell death & disease · 2018Article
- Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats.RSC advances · 2018Article
- Inhibitory effects of oxymatrine on TGF‑β1‑induced proliferation and abnormal differentiation in rat cardiac fibroblasts via the p38MAPK and ERK1/2 signaling pathways.Molecular medicine reports · 2017Article
- Effect of ALDH2 on High Glucose-Induced Cardiac Fibroblast Oxidative Stress, Apoptosis, and Fibrosis.Oxidative medicine and cellular longevity · 2017Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibrosis is an important, structurally damaging event that occurs in pathological cardiac remodeling, leading to cardiac dysfunction. BNIP3L is up-regulated in pressure overload-induced heart failure and has been reported to play an important role in cardiomyocyte apoptosis; however, its involvement in cardiac fibroblasts (CFs) remains unknown. We prove for the first time that the expression of BNIP3L is significantly increased in the CFs of rats undergoing pressure overload-induced heart failure. Furthermore, this increased BNIP3L expression was confirmed in cultured neonatal rat CFs undergoing proliferation and extracellular matrix (ECM) protein over-expression that was induced by norepinephrine (NE). The overexpression or suppression of BNIP3L promoted or inhibited NE-induced proliferation and ECM expression in CFs, respectively. In addition, [Ca
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