ArticleScientific reports2017
A novel indole compound MA-35 attenuates renal fibrosis by inhibiting both TNF-α and TGF-β
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Histone methylation of kidney disease: fact or fantasy?Renal failure · 2025Review
- Hypoglycemia and hyperinsulinemia induced by phenolic uremic toxins in CKD and DKD patients.Scientific reports · 2025Article
- Intestinal Fibrogenesis in Inflammatory Bowel Diseases: Exploring the Potential Role of Gut Microbiota Metabolites as Modulators.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Article
- Effectiveness comparison between ustekinumab and infliximab for Crohn's disease complicated with intestinal stenosis: a multicenter real-world study.Therapeutic advances in gastroenterology · 2024Article
- ELMO1 ameliorates intestinal epithelial cellular senescence via SIRT1/p65 signaling in inflammatory bowel disease-related fibrosis.Gastroenterology report · 2024Article
- Development of antifibrotic therapy for stricturing Crohn's disease: lessons from randomized trials in other fibrotic diseases.Physiological reviews · 2022Review
- Indole-Based Small Molecules as Potential Therapeutic Agents for the Treatment of Fibrosis.Frontiers in pharmacology · 2022Review
- Aryl Hydrocarbon Receptor Mechanisms Affecting Chronic Kidney Disease.Frontiers in pharmacology · 2022Review
- Are activated B cells involved in the process of myocardial fibrosis after acute myocardial infarction? An in vivo experiment.BMC cardiovascular disorders · 2021Article
- Drugs Repurposed as Antiferroptosis Agents Suppress Organ Damage, Including AKI, by Functioning as Lipid Peroxyl Radical Scavengers.Journal of the American Society of Nephrology : JASN · 2020Article
- The indole compound MA-35 attenuates tumorigenesis in an inflammation-induced colon cancer model.Scientific reports · 2019Article
- Gcm1 is involved in cell proliferation and fibrosis during kidney regeneration after ischemia-reperfusion injury.Scientific reports · 2019Article
- Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease.Nature communications · 2019Article
- Design and Synthesis of Matrine Derivatives as Novel Anti-Pulmonary Fibrotic Agents via Repression of the TGFβ/Smad Pathway.Molecules (Basel, Switzerland) · 2019Article
- Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis.Oxidative medicine and cellular longevity · 2019Review
- Angiotensin-converting enzyme inhibitor reduces scar formation by inhibiting both canonical and noncanonical TGF-β1 pathways.Scientific reports · 2018Article
- Modulation of NCAM/FGFR1 signaling suppresses EMT program in human proximal tubular epithelial cells.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 4 institutions in 2 countries.
Hisato ShimaDivision of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Kensuke SasakiDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, 734-8551, Japan.
Takehiro SuzukiDivision of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Chikahisa MukawaLaboratory of Oncology, Pharmacy Practice and Sciences, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, 980-8578, Japan.
Ten ObaraDepartment of Biology, Indiana University Purdue University Indianapolis, Indianapolis, IN, 46202, USA.
Yuki ObaDivision of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Akihiro MatsuoDivision of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Takayasu KobayashiCenter for Gene Research, Tohoku University, Sendai, 980-8575, Japan.
Eikan MishimaDivision of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.ORCID 0000-0002-3706-2745
Shun WatanabeDivision of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Yasutoshi AkiyamaDivision of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Koichi KikuchiDivision of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Tetsuro MatsuhashiDivision of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Sendai, 980-8574, Japan.
Yoshitsugu OikawaDivision of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Sendai, 980-8574, Japan.
Fumika NantoDivision of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Yukako AkiyamaDivision of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Hsin-Jung HoDivision of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Chitose SuzukiDivision of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Daisuke SaigusaDepartment of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8574, Japan.
Atsushi MasamuneDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Yoshihisa TomiokaLaboratory of Oncology, Pharmacy Practice and Sciences, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, 980-8578, Japan.
Takao MasakiDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, 734-8551, Japan.
Sadayoshi ItoDivision of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Ken-Ichiro HayashiDepartment of Biochemistry, Okayama University of Science, Okayama, 700-0005, Japan.
Takaaki AbeDivision of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan. takaabe@med.tohoku.ac.jp.
Tohoku University · JPHiroshima University Hospital · JPOkayama University of Science · JPUniversity of Indianapolis · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal fibrosis is closely related to chronic inflammation and is under the control of epigenetic regulations. Because the signaling of transforming growth factor-β
Indexed as
AnimalsCell LineDisease Models, AnimalExtracellular MatrixFibrosisHepatitisHistonesHumansI-kappa B KinaseIndolesKidney DiseasesLipopolysaccharidesMaleMethylationMiceModels, BiologicalHistonesI-kappa B KinaseIndolesLipopolysaccharidesSmad3 ProteinTransforming Growth Factor beta1Tumor Necrosis Factor-alpha
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.