ArticleScientific reports2017
A One-Pot Three-Component Double-Click Method for Synthesis of [
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Double-Click Strategy Combining CuAAC and (Thia-) Diels-Alder Reactions; Application Toward Peptide Labeling.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Localized Sustained Release of Copper Enhances Antitumor Effects of Disulfiram in Head and Neck Cancer.Biomacromolecules · 2024Article
- Click Chemistry and Radiochemistry: An Update.Bioconjugate chemistry · 2023Review
- Immuno-PET: Design options and clinical proof-of-concept.Frontiers in medicine · 2022Review
- Perspectives on metals-based radioimmunotherapy (RIT): moving forward.Theranostics · 2021Review
- Magnetic γFeBMC chemistry · 2020Article
- Oral uptake and persistence of the FnAb-8 protein characterized by in situ radio-labeling and PET/CT imaging.Asian journal of pharmaceutical sciences · 2020Article
- Evaluation of aMolecules (Basel, Switzerland) · 2020Article
- Monoclonal antibody-based molecular imaging strategies and theranostic opportunities.Theranostics · 2020Review
- Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio-Crosslinking.ChemPlusChem · 2019Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A one-pot three-component double-click process for preparing tumor-targeting agents for cancer radiotherapy is described here. By utilizing DOTA (or NOTA) containing tetrazines and the TCO-substituted aldehyde, the two click reactions, the tetrazine ligation (an inverse electron-demand Diels-Alder cycloaddition) and the RIKEN click (a rapid 6π-azaelectrocyclization), could simultaneously proceed under mild conditions to afford covalent attachment of the metal chelator DOTA or NOTA to biomolecules such as to albumin and anti-IGSF4 antibody without altering their activities. Subsequently, radiolabeling of DOTA- or NOTA-attached albumin and anti-IGSF4 antibody (an anti-tumor-targeting antibody) with [
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Registered trials
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