ArticleScientific reports2017
Cells reprogramming to stem cells inhibit the reprogramming of adjacent cells in the moss Physcomitrella patens.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- STEMIN transcription factor drives selective chromatin remodeling for gene activation within a relaxed chromatin during reprogramming in the moss Physcomitrium patens.The Plant journal : for cell and molecular biology · 2025Article
- Class II kinesin-12 facilitates cell plate formation by transporting cell plate materials in the phragmoplast.Nature plants · 2025Article
- Plant regeneration in the new era: from molecular mechanisms to biotechnology applications.Science China. Life sciences · 2024Review
- Overexpression ofAutophagy · 2022Article
- DNA damage triggers reprogramming of differentiated cells into stem cells in Physcomitrella.Nature plants · 2020Article
- The MossThe Plant cell · 2020Review
- A Comprehensive Toolkit for Quick and Easy Visualization of Marker Proteins, Protein-Protein Interactions and Cell Morphology inFrontiers in plant science · 2020Article
- A versatile microfluidic device for highly inclined thin illumination microscopy in the moss Physcomitrella patens.Scientific reports · 2019Article
- Single-cell transcriptome analysis of Physcomitrella leaf cells during reprogramming using microcapillary manipulation.Nucleic acids research · 2019Article
- Kinetochore protein depletion underlies cytokinesis failure and somatic polyploidization in the mosseLife · 2019Article
- Antheridial development in the mossPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Under certain circumstances differentiated cells can be reprogrammed to form stem cells in land plants, but only a portion of the cells reprograms successfully. A long-distance inhibitory signal from reprogrammed cells to surrounding cells has been reported in some ferns. Here we show the existence of anisotropic inhibitory signal to regulate stem cell formation in the moss Physcomitrella patens. When single cells were isolated from a gametophore leaf, over 90% of them were reprogrammed to stem cells with characteristic nuclear expansion. By contrast, when two adjacent cells were isolated, the nuclei of both cells expanded, but successful reprogramming of both cells occurred only in approximately one fifth of the pairs. When three aligned cells were isolated, the reprogramming rate of both edge cells decreased with a living middle cell but did not with a dead middle cell. Furthermore, unequal conversion into stem cells was more prominent in cell pairs aligned parallel to the proximal-distal leaf axis than in those perpendicular to the axis. This study gives an insight into the role of the inhibitory signal in development and evolution as well as the efficient stem cell induction from differentiated cells.
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