Evidence map›Paper›PMID 28507241›Full record

ArticleJournal of bacteriology2017

An Amino Acid Substitution in RNA Polymerase That Inhibits the Utilization of an Alternative Sigma Factor.

Anna F Wang Erickson, Padraig Deighan, Cinthia P Garcia, Robert O J Weinzierl, Ann Hochschild, Richard Losick

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Anna F Wang EricksonDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA.
Padraig DeighanDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
Cinthia P GarciaDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
Robert O J WeinzierlDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Ann HochschildDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
Richard LosickDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA losick@mcb.harvard.edu.
Harvard University · USImperial College London · GB

Funding

Role of RNA Polymerase in Bacterial DifferentionR01GM018568 · NIGMS · HARVARD UNIVERSITY · PI LOSICK, RICHARD MARC · 1985 to 2018
$11.5M
PROTEIN/PROTEIN INTERACTIONS IN PROKARYOTIC GENE CONTROLR01GM044025 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI HOCHSCHILD, ANN · 1990 to 2015
$8.1M
NIGMS NIH HHS R01 GM018568NIGMS NIH HHS R01 GM044025
6 · The paper itself

Abstract

Sigma (σ) factors direct gene transcription by binding to and determining the promoter recognition specificity of RNA polymerase (RNAP) in bacteria. Genes transcribed under the control of alternative sigma factors allow cells to respond to stress and undergo developmental processes, such as sporulation in

Indexed as

Sigma FactorAmino Acid SubstitutionBacillus subtilisBacterial ProteinsConserved SequenceDNA-Directed RNA PolymerasesEscherichia coliGene Expression Regulation, BacterialGene Expression Regulation, EnzymologicModels, MolecularProtein ConformationBacterial ProteinsDNA-Directed RNA PolymerasesSigma FactorRNA polymerasesigma factorsporulationtranscription

Identifiers

PMID28507241
PMCPMC5494745
OpenAlexW2615258929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.