ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2017
Dynamics of the cell-mediated immune response to tumour growth.
Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Harnessing Nonlinear Mechanics to Transform Medical Diagnostics.Applied mechanics reviews · 2025Article
- Data-driven learning how oncogenic gene expression locally alters heterocellular networks.Nature communications · 2022Article
- CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors.eLife · 2019Article
- AXL Is a Putative Tumor Suppressor and Dormancy Regulator in Prostate Cancer.Molecular cancer research : MCR · 2019Article
- Mathematical methods in medicine: neuroscience, cardiology and pathology.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2017Review
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Authors and funding
3 authors.
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Abstract
Using a hybrid cellular automaton, we investigate the transient and asymptotic dynamics of the cell-mediated immune response to tumour growth. We analyse the correspondence between this dynamics and the three phases of the theory of immunoedition: elimination, equilibrium and escape. Our results demonstrate that the immune system can keep a tumour dormant for long periods of time, but that this dormancy is based on a frail equilibrium between the mechanisms that spur the immune response and the growth of the tumour. Thus, we question the capacity of the cell-mediated immune response to sustain long periods of dormancy, as those appearing in recurrent disease. We suggest that its role might be rather to synergize with other types of tumour dormancy.This article is part of the themed issue 'Mathematical methods in medicine: neuroscience, cardiology and pathology'.
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