ArticleProceedings of the National Academy of Sciences of the United States of America2017
Linkage disequilibrium matches forensic genetic records to disjoint genomic marker sets.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Toward minimal SNP sets for record-matching with CODIS STR profiles.European journal of human genetics : EJHG · 2026Article
- Autosomal str allele frequencies, forensic parameters and population structure in four underrepresented indigenous groups from Paraguay.International journal of legal medicine · 2026Article
- A Biomedical Researcher's Guide for Analyzing Short Tandem Repeat (STR) Genotypes of Human Cell Lines and in Vitro Tissue Samples Using Three Standard Authentication Algorithms.Current protocols · 2026Article
- DNA Mixture Deconvolution: A Four-Strategy Framework from Physical Separation to Database Searching.Genes · 2026Review
- Reflections on the Human Genome Diversity Project: a conversation with Marcus W. Feldman, Henry T. Greely, and Mary-Claire King.Genetics · 2026Article
- Rootless hair as a reliable source of forensic genetic information.Genome biology · 2026Article
- Do forensic genetic markers disclose more information about us than they should? (A review).International journal of legal medicine · 2025Review
- Article
- Safe Utilization and Sharing of Genomic Data: Amendment to the Health and Medical Data Utilization Guidelines of South Korea.Cancer research and treatment · 2024Article
- Assessing Privacy Vulnerabilities in Genetic Data Sets: Scoping Review.JMIR bioinformatics and biotechnology · 2024Article
- Solving the Arizona search problem by imputation.iScience · 2024Article
- Record-matching of STR profiles with fragmentary genomic SNP data.European journal of human genetics : EJHG · 2023Article
- Microsatellites used in forensics are in regions enriched for trait-associated variants.iScience · 2023Article
- Microsatellites used in forensics are located in regions unusually rich in trait-associated variants.bioRxiv : the preprint server for biology · 2023Article
- Gattaca as a lens on contemporary genetics: marking 25 years into the film's "not-too-distant" future.Genetics · 2022Article
- Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Sociotechnical safeguards for genomic data privacy.Nature reviews. Genetics · 2022Review
- Using game theory to thwart multistage privacy intrusions when sharing data.Science advances · 2021Article
- mixIndependR: a R package for statistical independence testing of loci in database of multi-locus genotypes.BMC bioinformatics · 2021Article
- DNA Data Collection and Analysis in the Forensic Arena.Methods in molecular biology (Clifton, N.J.) · 2021Article
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Authors and funding
5 authors.
Funding
Abstract
Combining genotypes across datasets is central in facilitating advances in genetics. Data aggregation efforts often face the challenge of record matching-the identification of dataset entries that represent the same individual. We show that records can be matched across genotype datasets that have no shared markers based on linkage disequilibrium between loci appearing in different datasets. Using two datasets for the same 872 people-one with 642,563 genome-wide SNPs and the other with 13 short tandem repeats (STRs) used in forensic applications-we find that 90-98% of forensic STR records can be connected to corresponding SNP records and vice versa. Accuracy increases to 99-100% when ∼30 STRs are used. Our method expands the potential of data aggregation, but it also suggests privacy risks intrinsic in maintenance of databases containing even small numbers of markers-including databases of forensic significance.
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