Evidence map›Paper›PMID 28507136›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

OCD candidate gene

Isaac D Zike, Muhammad O Chohan, Jared M Kopelman, Emily N Krasnow, Daniel Flicker, Katherine M Nautiyal, Michael Bubser, Christoph Kellendonk, Carrie K Jones, Gregg Stanwood and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Novel mouse line with D277N mutation in theFrontiers in cell and developmental biology · 2026
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  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Computational insights on asymmetricalCognitive neurodynamics · 2024
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Midbrain dopamine neurons arbiter OCD-like behavior.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Isaac D ZikeDepartment of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232.
Muhammad O ChohanNew York State Psychiatric Institute, New York, NY 10032.
Jared M KopelmanDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260.
Emily N KrasnowNew York State Psychiatric Institute, New York, NY 10032.
Daniel FlickerHoward Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.
Katherine M NautiyalDepartment of Psychiatry, Columbia University Medical Center, New York, NY 10032.
Michael BubserVanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232.
Christoph KellendonkDepartment of Psychiatry, Columbia University Medical Center, New York, NY 10032.
Carrie K JonesDepartment of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232.
Gregg StanwoodDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32304.
Kenji Fransis TanakaDepartment of Neuropsychiatry, School of Medicine, Keio University, Tokyo 108-8345, Japan.
Holly MooreNew York State Psychiatric Institute, New York, NY 10032.
Susanne E AhmariDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260; veenstr@nyspi.columbia.edu ahmarise@upmc.edu.
Jeremy Veenstra-VanderWeeleNew York State Psychiatric Institute, New York, NY 10032; veenstr@nyspi.columbia.edu ahmarise@upmc.edu.ORCID 0000-0002-6349-1076
Columbia University Irving Medical Center · USNew York State Psychiatric InstituteVanderbilt University Medical Center · USUniversity of Pittsburgh · USBroad Institute · USFlorida State University · USKeio University · JP

Funding

Investigation of EAAT3 in OCD PathophysiologyR01MH114296 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI AHMARI, SUSANNE ELIZABETH, VEENSTRA-VANDERWEELE, JEREMY · 2017 to 2021
$2.7M
Translating OCD gene-association studies into mice to examine SLC1A1 functionR21MH096200 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AHMARI, SUSANNE ELIZABETH, VEENSTRA-VANDERWEELE, JEREMY · 2012 to 2013
$419k
Howard Hughes Medical InstituteNIMH NIH HHS R01 MH114296NIMH NIH HHS R21 MH096200
6 · The paper itself

Abstract

Obsessive-compulsive disorder (OCD) is a chronic, disabling condition with inadequate treatment options that leave most patients with substantial residual symptoms. Structural, neurochemical, and behavioral findings point to a significant role for basal ganglia circuits and for the glutamate system in OCD. Genetic linkage and association studies in OCD point to

Indexed as

AmphetaminesAnimalsBasal GangliaCell LineCentral Nervous System StimulantsDopamineExcitatory Amino Acid Transporter 3Glutamic AcidGroomingMaze LearningMiceMice, Inbred C57BLMice, TransgenicMotor ActivityObsessive-Compulsive DisorderReceptors, Dopamine D1AmphetaminesCentral Nervous System StimulantsDopamineExcitatory Amino Acid Transporter 3Glutamic AcidReceptors, Dopamine D1Slc1a1 protein, mousebasal gangliadopamineEAAC1obsessive-compulsive disorderTourette

Identifiers

PMID28507136
PMCPMC5465902
OpenAlexW2615511331

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.