Evidence map›Paper›PMID 28507099›Full record

ArticleThe Journal of biological chemistry2017

Carbon dioxide-dependent regulation of NF-κB family members RelB and p100 gives molecular insight into CO

Ciara E Keogh, Carsten C Scholz, Javier Rodriguez, Andrew C Selfridge, Alexander von Kriegsheim, Eoin P Cummins

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. COeLife · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
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  18. Article
  19. Effects of elevated CORespiratory research · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 4 countries.

Ciara E KeoghFrom the School of Medicine and Conway Institute and.
Carsten C ScholzSystems Biology Ireland, University College Dublin, Dublin 4, Ireland.ORCID 0000-0001-6579-8015
Javier RodriguezSystems Biology Ireland, University College Dublin, Dublin 4, Ireland.
Andrew C SelfridgeFrom the School of Medicine and Conway Institute and.
Alexander von KriegsheimSystems Biology Ireland, University College Dublin, Dublin 4, Ireland.
Eoin P CumminsFrom the School of Medicine and Conway Institute and eoin.cummins@ucd.ie.ORCID 0000-0002-9346-8299
University College Dublin · IEConway School of Landscape Design · USCummins (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CO

Indexed as

A549 CellsAnimalsCarbon DioxideHumansHypercapniaMiceNF-kappa B p52 SubunitProtein DomainsSignal TransductionTranscription Factor RelBTranscription, GeneticCarbon DioxideNF-kappa B p52 SubunitNFKB2 protein, humanNfkb2 protein, mouseRELB protein, humanRelb protein, mouseTranscription Factor RelBcarbon dioxidechronic obstructive pulmonary disease (COPD)CO2hypercapniaimmunityinflammationinnate immunityNF-κB transcription factorp100RelB

Identifiers

PMID28507099
PMCPMC5500817
OpenAlexW2614717441

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.