Evidence map›Paper›PMID 28507097›Full record

ArticleThe Journal of biological chemistry2017

Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2.

Brandon L Logeman, L Kent Wood, Jaekwon Lee, Dennis J Thiele

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 38 citations in OpenAlex.

  1. Metallothionein and neurodegenerative diseases.Neural regeneration research · 2026
    Article
  2. Transcriptomic and proteomic ramifications of segmental amplification inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Copper in Gynecological Diseases.International journal of molecular sciences · 2023
    Review
  7. Review
  8. Article
  9. Copper metabolism as a unique vulnerability in cancer.Biochimica et biophysica acta. Molecular cell research · 2021
    Review
  10. Review
  11. Review
  12. Article
  13. Article
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Brandon L LogemanFrom the Departments of Pharmacology and Cancer Biology.ORCID 0000-0002-9975-3541
L Kent WoodMolecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina 27710 and.
Jaekwon Leethe Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, Nebraska 68588.
Dennis J ThieleFrom the Departments of Pharmacology and Cancer Biology, dennis.thiele@duke.edu.
Centre for Cancer Biology · AUDuke University · USThiel College · USUniversity of Nebraska–Lincoln · US

Funding

Copper Homeostasis in MammalsR01DK074192 · NIDDK · DUKE UNIVERSITY · PI MATSUNAMI, HIROAKI · 2006 to 2021
$5.2M
Redox Biology CenterP30GM103335 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI BECKER, DONALD F · 2012 to 2016
$4.3M
Mechanistic insights into homeostatic copper acquistionR01DK079209 · NIDDK · UNIVERSITY OF NEBRASKA LINCOLN · PI LEE, JAEKWON · 2007 to 2014
$1.9M
NIDDK NIH HHS R01 DK074192NIDDK NIH HHS R01 DK079209NIGMS NIH HHS P30 GM103335
6 · The paper itself

Abstract

Copper is an essential element for proper organismal development and is involved in a range of processes, including oxidative phosphorylation, neuropeptide biogenesis, and connective tissue maturation. The copper transporter (Ctr) family of integral membrane proteins is ubiquitously found in eukaryotes and mediates the high-affinity transport of Cu

Indexed as

Cation Transport ProteinsEvolution, MolecularGene DuplicationPhylogenyAnimalsCopperCopper Transporter 1Embryo, MammalianFibroblastsHumansIon TransportMiceMice, KnockoutSLC31 ProteinsCation Transport ProteinsCopperCopper Transporter 1SLC31A1 protein, humanSlc31a1 protein, mouseSLC31A2 protein, humanSlc31a2 protein, mouseSLC31 Proteinscoppercopper transportCtr1Ctr2evolutionmetal homeostasisyeast

Identifiers

PMID28507097
PMCPMC5500815
OpenAlexW2616652505

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.