Evidence map›Paper›PMID 28507080›Full record

ArticleThe Journal of general physiology2017

Divergent roles of a peripheral transmembrane segment in AMPA and NMDA receptors.

Johansen B Amin, Catherine L Salussolia, Kelvin Chan, Michael C Regan, Jian Dai, Huan-Xiang Zhou, Hiro Furukawa, Mark E Bowen, Lonnie P Wollmuth

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of general physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Molecular Mechanisms of AMPA Receptor Trafficking in the Nervous System.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. AMPA receptor structure and auxiliary subunits.The Journal of physiology · 2021
    Review
  17. Article
  18. Article
  19. A Model to Study NMDA Receptors in Early Nervous System Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  20. CaBiophysical journal · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Johansen B AminGraduate Program in Cellular and Molecular Pharmacology, Stony Brook University, Stony Brook, NY 11794.
Catherine L SalussoliaDepartment of Pediatrics, Pediatrics Residency Program, Stony Brook University, Stony Brook, NY 11794.ORCID http://orcid.org/0000-0003-0168-3205
Kelvin ChanGraduate Program in Neuroscience, Stony Brook University, Stony Brook, NY 11794.
Michael C ReganCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.
Jian DaiDepartment of Physics, Florida State University, Tallahassee, FL 32306.
Huan-Xiang ZhouDepartment of Physics, Florida State University, Tallahassee, FL 32306.ORCID http://orcid.org/0000-0001-9020-0302
Hiro FurukawaCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.
Mark E BowenDepartment of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794.
Lonnie P WollmuthDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794 lonnie.wollmuth@stonybrook.edu.ORCID http://orcid.org/0000-0002-8179-1259
Stony Brook University · USCold Spring Harbor Laboratory · USFlorida State University · US

Funding

Structures and reagents of NMDA receptorsR01MH085926 · NIMH · COLD SPRING HARBOR LABORATORY · PI Hiroyasu Furukawa · 2010 to 2026
$8.9M
Quantitative, Mechanistic Studies of Biomolecular RecognitionR35GM118091 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Huan-Xiang Zhou · 2016 to 2026
$6.5M
SINGLE MOLECULE ANALYSIS OF PSD-95 STRUCTURE AND LIGAND BINDINGR01MH081923 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI BOWEN, MARK E · 2008 to 2022
$5.6M
Minority Supplement for Noele CertainR01NS088479 · NINDS · STATE UNIVERSITY NEW YORK STONY BROOK · PI WOLLMUTH, LONNIE P · 2015 to 2023
$3.9M
STRUCTURE AND FUNCTION OF HETERO-MULTIMERIC GLUTAMATE RECEPTORSR01GM105730 · NIGMS · COLD SPRING HARBOR LABORATORY · PI FURUKAWA, HIROYASU · 2014 to 2017
$2.0M
Structural Basis of Allosteric Regulation in the NMDA ReceptorF32NS093753 · NINDS · COLD SPRING HARBOR LABORATORY · PI REGAN, MICHAEL CASEY · 2015 to 2018
$167k
NIGMS NIH HHS R01 GM105730NIGMS NIH HHS R35 GM118091NIMH NIH HHS R01 MH081923NIMH NIH HHS R01 MH085926NINDS NIH HHS F32 NS093753NINDS NIH HHS R01 NS088479
6 · The paper itself

Abstract

Ionotropic glutamate receptors (iGluRs), including AMPA receptor (AMPAR) and NMDA receptor (NMDAR) subtypes, are ligand-gated ion channels that mediate signaling at the majority of excitatory synapses in the nervous system. The iGluR pore domain is structurally and evolutionarily related to an inverted two-transmembrane K

Indexed as

Evolution, MolecularAnimalsHEK293 CellsHumansIon Channel GatingProtein DomainsProtein MultimerizationRatsReceptors, AMPAReceptors, N-Methyl-D-AspartateReceptors, AMPAReceptors, N-Methyl-D-Aspartate

Identifiers

PMID28507080
PMCPMC5460951
OpenAlexW2616806487

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.