Evidence map›Paper›PMID 28507079›Full record

ArticleThe Journal of general physiology2017

Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes.

Sendoa Tajada, Claudia M Moreno, Samantha O'Dwyer, Sean Woods, Daisuke Sato, Manuel F Navedo, L Fernando Santana

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of general physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 47 citations in OpenAlex.

  1. Guidelines for evaluating endothelial function in vascular tissue.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  2. Cerebral capillary computation.American journal of physiology. Cell physiology · 2026
    Review
  3. Review
  4. Article
  5. Electro-metabolic signaling.The Journal of general physiology · 2024
    Article
  6. Vascular mechanotransduction.Physiological reviews · 2023
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Activation of TRPV4 channels leads to a consistent tocolytic effect on human myometrial tissues.European journal of obstetrics & gynecology and reproductive biology: X · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. TRPML1 channels initiate CaScience signaling · 2020
    Article
  17. βAnnual review of pharmacology and toxicology · 2020
    Review
  18. Calcium Permeable Channels in Cancer Hallmarks.Frontiers in pharmacology · 2020
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sendoa TajadaDepartment of Physiology and Membrane Biology, University of California Davis School of Medicine, Davis, CA.ORCID http://orcid.org/0000-0002-5138-9808
Claudia M MorenoDepartment of Physiology and Membrane Biology, University of California Davis School of Medicine, Davis, CA.
Samantha O'DwyerDepartment of Physiology and Membrane Biology, University of California Davis School of Medicine, Davis, CA.
Sean WoodsDepartment of Physiology and Membrane Biology, University of California Davis School of Medicine, Davis, CA.
Daisuke SatoDepartment of Pharmacology, University of California Davis School of Medicine, Davis, CA.ORCID http://orcid.org/0000-0001-9341-0970
Manuel F NavedoDepartment of Pharmacology, University of California Davis School of Medicine, Davis, CA.ORCID http://orcid.org/0000-0001-6864-6594
L Fernando SantanaDepartment of Physiology and Membrane Biology, University of California Davis School of Medicine, Davis, CA lfsantana@ucdavis.edu.ORCID http://orcid.org/0000-0002-4297-8029
University of California, Davis · US

Funding

Coupling of Vascular Cav1.2 Channels In Health & DiseaseR01HL121059 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2015 to 2024
$4.5M
Persistent Calcium Sparklets in Vascular Smooth MuscleR01HL085870 · NHLBI · UNIVERSITY OF WASHINGTON · PI SANTANA, LUIS F · 2007 to 2016
$3.9M
Calcium Sparklets-Induced Vascular Dysfunction During DiabetesR01HL098200 · NHLBI · UNIVERSITY OF WASHINGTON · PI NAVEDO, MANUEL F · 2010 to 2019
$3.5M
Predoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2M
Regulations of Myoendothelial Function By Signaling Microdomains in HypertensionR01HL121706 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2014 to 2017
$1.6M
Modeling of Cardiac Calcium Dynamics; Ryanodine Receptor induced ArrhythmiasR00HL111334 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SATO, DAISUKE · 2015 to 2017
$738k
Modeling of Cardiac Calcium Dynamics; Ryanodine Receptor induced ArrhythmiasK99HL111334 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SATO, DAISUKE · 2012 to 2013
$194k
NHLBI NIH HHS K99 HL111334NHLBI NIH HHS R00 HL111334NHLBI NIH HHS R01 HL085870NHLBI NIH HHS R01 HL098200NHLBI NIH HHS R01 HL121059NHLBI NIH HHS R01 HL121706NIGMS NIH HHS T32 GM099608
6 · The paper itself

Abstract

TRPV4 (transient receptor potential vanilloid 4) channels are Ca

Indexed as

Action PotentialsA Kinase Anchor ProteinsAngiotensin IIAnimalsArteriesCalciumCell MembraneCells, CulturedFemaleIon Channel GatingMaleMiceMice, Inbred C57BLMuscle CellsProtein BindingProtein Kinase C-alphaAkap5 protein, mouseA Kinase Anchor ProteinsAngiotensin IICalciumProtein Kinase C-alphaTrpv4 protein, mouseTRPV Cation Channels

Identifiers

PMID28507079
PMCPMC5460949
OpenAlexW2616752942

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.