Evidence map›Paper›PMID 28507063›Full record

ArticleInfection and immunity2017

The Mycobacterium tuberculosis MmpL11 Cell Wall Lipid Transporter Is Important for Biofilm Formation, Intracellular Growth, and Nonreplicating Persistence.

Catherine C Wright, Fong Fu Hsu, Eusondia Arnett, Jennifer L Dunaj, Patrick M Davidson, Sophia A Pacheco, Melanie J Harriff, David M Lewinsohn, Larry S Schlesinger, Georgiana E Purdy

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Role of bacterial multidrug efflux pumps during infection.World journal of microbiology & biotechnology · 2024
    Review
  12. Article
  13. Article
  14. M. tuberculosis AlkX Encoded byMicrobiology spectrum · 2022
    Article
  15. Phenotypic adaptation ofFrontiers in cellular and infection microbiology · 2022
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Catherine C WrightDepartment of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Fong Fu HsuDepartment of Internal Medicine, Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, USA.
Eusondia ArnettDepartment of Microbial Infection and Immunity, Center for Microbial Interface Biology, The Ohio State University, Columbus, Ohio, USA.
Jennifer L DunajDepartment of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Patrick M DavidsonDepartment of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Sophia A PachecoDepartment of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Melanie J HarriffPortland Veterans Administration Medical Center, Portland, Oregon, USA.
David M LewinsohnDepartment of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Larry S SchlesingerDepartment of Microbial Infection and Immunity, Center for Microbial Interface Biology, The Ohio State University, Columbus, Ohio, USA.
Georgiana E PurdyDepartment of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA purdyg@ohsu.edu.
Oregon Health & Science University · USThe Ohio State University · USPortland VA Medical Center · USWashington University in St. Louis · US

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Jennifer Lynn Powers Carson · 2013 to 2026
$27.1M
TrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0M
A Biomedical Mass Spectrometry Resource: Ongoing Driving Biomedical ProjectsR24GM136766 · NIGMS · WASHINGTON UNIVERSITY · PI GROSS, MICHAEL L · 2020 to 2022
$2.3M
TB Membrane Transporters and Intrinsic ResistanceR01AI087840 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI PURDY, GEORGIANA E. · 2011 to 2015
$1.9M
Lipidomic Screening For Functional Surfactant Gene MutationsR33HL120760 · NHLBI · WASHINGTON UNIVERSITY · PI COLE, FRANCIS SESSIONS · 2016 to 2018
$1.4M
Lipidomic Screening For Functional Surfactant Gene MutationsR21HL120760 · NHLBI · WASHINGTON UNIVERSITY · PI COLE, FRANCIS SESSIONS · 2014 to 2015
$441k
The MmpL11 interactomeR21AI113074 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI PURDY, GEORGIANA E. · 2015 to 2016
$424k
NHLBI NIH HHS R21 HL120760NHLBI NIH HHS R33 HL120760NIAID NIH HHS R01 AI087840NIAID NIH HHS R21 AI113074NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341NIGMS NIH HHS P41 GM103422NIGMS NIH HHS R24 GM136766
6 · The paper itself

Abstract

The mycobacterial cell wall is crucial to the host-pathogen interface, because it provides a barrier against antibiotics and the host immune response. In addition, cell wall lipids are mycobacterial virulence factors. The

Indexed as

Bacterial ProteinsBiofilmsBiological TransportCell WallCytoplasmLipidsMembrane ProteinsMembrane Transport ProteinsMutationMycobacterium tuberculosisVirulence FactorsBacterial ProteinsLipidsMembrane ProteinsMembrane Transport ProteinsMmpL3 protein, Mycobacterium tuberculosisVirulence Factorsbiofilmcell wallgranulomalipid transportlipid transporterMmpL11Mycobacterium tuberculosisnonreplicating persistencetuberculosis

Identifiers

PMID28507063
PMCPMC5520431
OpenAlexW2616315171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.