Evidence map›Paper›PMID 28507062›Full record

ArticleThe Journal of experimental medicine2017

Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths.

Victoria S Pelly, Stephanie M Coomes, Yashaswini Kannan, Manolis Gialitakis, Lewis J Entwistle, Jimena Perez-Lloret, Stephanie Czieso, Isobel S Okoye, Dominik Rückerl, Judith E Allen and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Regulatory T cell memory: implications for malaria.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Regulatory T cells in allergic inflammation.Seminars in immunology · 2023
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Mechanisms of exTreg induction.European journal of immunology · 2021
    Review
  13. Article
  14. Review
  15. Ex-TFRs: A Missing Piece of the SLE Puzzle?Frontiers in immunology · 2021
    Review
  16. Article
  17. Microbiota-Propelled T Helper 17 Cells in Inflammatory Diseases and Cancer.Microbiology and molecular biology reviews : MMBR · 2020
    Review
  18. ncRNAs in Type-2 Immunity.Non-coding RNA · 2020
    Review
  19. Article
  20. Mechanisms of Dupilumab.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Victoria S PellyAllergy and Anti-Helminth Immunity Laboratory, Mill Hill Laboratory, The Francis Crick Institute, London NW7 1AA, England, UK.ORCID 0000-0002-7273-0104
Stephanie M CoomesAllergy and Anti-Helminth Immunity Laboratory, Mill Hill Laboratory, The Francis Crick Institute, London NW7 1AA, England, UK.
Yashaswini KannanAllergy and Anti-Helminth Immunity Laboratory, Mill Hill Laboratory, The Francis Crick Institute, London NW7 1AA, England, UK.
Manolis GialitakisAhr Immunity Laboratory, Mill Hill Laboratory, The Francis Crick Institute, London NW7 1AA, England, UK.ORCID 0000-0001-5922-1922
Lewis J EntwistleAllergy and Anti-Helminth Immunity Laboratory, Mill Hill Laboratory, The Francis Crick Institute, London NW7 1AA, England, UK.
Jimena Perez-LloretAllergy and Anti-Helminth Immunity Laboratory, Mill Hill Laboratory, The Francis Crick Institute, London NW7 1AA, England, UK.
Stephanie CziesoAllergy and Anti-Helminth Immunity Laboratory, Mill Hill Laboratory, The Francis Crick Institute, London NW7 1AA, England, UK.
Isobel S OkoyeAllergy and Anti-Helminth Immunity Laboratory, Mill Hill Laboratory, The Francis Crick Institute, London NW7 1AA, England, UK.ORCID 0000-0001-6399-1591
Dominik RückerlFaculty of Life Sciences (3IR), University of Manchester, Manchester M13 9PT, England, UK.ORCID 0000-0002-0206-1451
Judith E AllenFaculty of Life Sciences (3IR), University of Manchester, Manchester M13 9PT, England, UK.ORCID 0000-0002-3829-066X
Frank BrombacherInternational Centre for Genetic Engineering and Biotechnology, University of Cape Town, Institute of Infectious Disease and Molecular Medicine and South African Medical Research Council, 7925 Cape Town, South Africa.ORCID 0000-0001-8881-6781
Mark S WilsonAllergy and Anti-Helminth Immunity Laboratory, Mill Hill Laboratory, The Francis Crick Institute, London NW7 1AA, England, UK wilson.mark@gene.com.ORCID 0000-0003-1737-1281
The Francis Crick Institute · GBUniversity of Manchester · GBSouth African Medical Research Council · ZA

Funding

Cancer Research UK FC001220Medical Research Council FC001220Medical Research Council MR/K01207X/1Medical Research Council MR/K01207X/2Wellcome TrustWellcome Trust FC001220
6 · The paper itself

Abstract

Immunity to intestinal helminth infections requires the rapid activation of T helper 2 cells (Th2 cells). However, simultaneous expansion of CD4

Indexed as

ImmunityAdoptive TransferAnimalsCell PolarityForkhead Transcription FactorsGene Expression ProfilingInterleukin-4IntestinesMice, Inbred C57BLNematospiroides dubiusReceptors, Interleukin-4Signal TransductionStrongylida InfectionsTh2 CellsT-Lymphocytes, RegulatoryForkhead Transcription FactorsFoxp3 protein, mouseInterleukin-4Receptors, Interleukin-4

Identifiers

PMID28507062
PMCPMC5460998
OpenAlexW2616838417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.