Evidence map›Paper›PMID 28507032›Full record

ArticleLearning & memory (Cold Spring Harbor, N.Y.)2017

α2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice.

Shahrdad Lotfipour, Celina Mojica, Sakura Nakauchi, Marcela Lipovsek, Sarah Silverstein, Jesse Cushman, James Tirtorahardjo, Andrew Poulos, Ana Belén Elgoyhen, Katumi Sumikawa and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Learning & memory (Cold Spring Harbor, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Imaging [bioRxiv : the preprint server for biology · 2026
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  5. "Unraveling the role ofReceptors (Basel, Switzerland) · 2025
    Article
  6. Article
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  8. Relationship BetweenJournal of Alzheimer's disease reports · 2023
    Article
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  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Enhanced Sensory-Cognitive Processing by Activation of Nicotinic Acetylcholine Receptors.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Shahrdad LotfipourDepartment of Psychiatry, University of California, Los Angeles, Los Angeles, California 90095, USA.ORCID 0000-0002-2425-1096
Celina MojicaDepartment of Psychiatry, University of California, Los Angeles, Los Angeles, California 90095, USA.
Sakura NakauchiDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92612, USA.
Marcela LipovsekInstituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr. Héctor N Torres, CONICET, Buenos Aires, C1428ADN, Argentina.
Sarah SilversteinDepartment of Psychiatry, University of California, Los Angeles, Los Angeles, California 90095, USA.
Jesse CushmanDepartment of Psychology, University of California, Los Angeles, Los Angeles, California 90095, USA.
James Tirtorahardjo
Andrew PoulosDepartment of Psychology, University of California, Los Angeles, Los Angeles, California 90095, USA.
Ana Belén ElgoyhenInstituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr. Héctor N Torres, CONICET, Buenos Aires, C1428ADN, Argentina.
Katumi SumikawaDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92612, USA.
Michael S FanselowDepartment of Psychiatry, University of California, Los Angeles, Los Angeles, California 90095, USA.
Jim BoulterDepartment of Psychiatry, University of California, Los Angeles, Los Angeles, California 90095, USA.
University of California, Los Angeles · USConsejo Nacional de Investigaciones Científicas y Técnicas · ARUniversity of California, Irvine · USAlbany State University · US

Funding

Contextual Fear Differentiation, Sex Differences and AcetylcholineR01MH062122 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FANSELOW, MICHAEL S · 2001 to 2021
$7.3M
Maternal nicotine exposure and development of hippocampal circuitsR01DA026458 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI SUMIKAWA, KATUMI · 2009 to 2013
$1.7M
NIDA NIH HHS R01 DA026458NIMH NIH HHS R01 MH062122
6 · The paper itself

Abstract

The absence of α2* nicotinic acetylcholine receptors (nAChRs) in oriens lacunosum moleculare (OLM) GABAergic interneurons ablate the facilitation of nicotine-induced hippocampal CA1 long-term potentiation and impair memory. The current study delineated whether genetic mutations of α2* nAChRs (

Indexed as

Action PotentialsAnimalsAnxietyConditioning, ClassicalDisease Models, AnimalExcitatory Postsynaptic PotentialsFearHippocampusLearning DisabilitiesLocomotionMaleMiceMice, Inbred C57BLMice, TransgenicNicotineNicotinic AgonistsCHRNA2 protein, mouseNicotineNicotinic AgonistsReceptors, Nicotinic

Identifiers

PMID28507032
PMCPMC5435881
OpenAlexW2616862112

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.