Evidence map›Paper›PMID 28506996›Full record

ArticleDevelopment (Cambridge, England)2017

RET-mediated glial cell line-derived neurotrophic factor signaling inhibits mouse prostate development.

Hyun-Jung Park, Eric C Bolton

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hyun-Jung ParkDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0002-4589-2052
Eric C BoltonDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA boltonec@life.illinois.edu.ORCID 0000-0002-3659-5697
University of Illinois Urbana-Champaign · US

Funding

AR and GDNF signaling tune growth and differentiation in the developing prostateR56DK109149 · NIDDK · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BOLTON, ERIC C · 2016 to 2016
$119k
NIDDK NIH HHS R56 DK109149
6 · The paper itself

Abstract

In humans and rodents, the prostate gland develops from the embryonic urogenital sinus (UGS). The androgen receptor (AR) is thought to control the expression of morphogenetic genes in inductive UGS mesenchyme, which promotes proliferation and cytodifferentiation of the prostatic epithelium. However, the nature of the AR-regulated morphogenetic genes and the mechanisms whereby AR controls prostate development are not understood. Glial cell line-derived neurotrophic factor (GDNF) binds GDNF family receptor α1 (GFRα1) and signals through activation of RET tyrosine kinase. Gene disruption studies in mice have revealed essential roles for GDNF signaling in development; however, its role in prostate development is unexplored. Here, we establish novel roles of GDNF signaling in mouse prostate development. Using an organ culture system for prostate development and

Indexed as

ActinsAnimalsCell DifferentiationCell ProliferationDihydrotestosteroneFemaleGlial Cell Line-Derived Neurotrophic FactorGlial Cell Line-Derived Neurotrophic Factor ReceptorsHumansMaleMiceMice, Inbred C57BLMice, Mutant StrainsMice, TransgenicMorphogenesisOrgan Culture TechniquesActinsAR protein, mouseDihydrotestosteroneGdnf protein, mouseGfra1 protein, mouseGlial Cell Line-Derived Neurotrophic FactorGlial Cell Line-Derived Neurotrophic Factor ReceptorsProto-Oncogene Proteins c-retReceptors, AndrogenRet protein, mouseAndrogen receptorGDNFGFRα1Prostate developmentRETUrogenital sinus

Identifiers

PMID28506996
PMCPMC5482989
OpenAlexW2614473704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.