Trial reportThe Journal of allergy and clinical immunology2017
A short course of gamma-tocopherol mitigates LPS-induced inflammatory responses in humans ex vivo.
Registry-linked trialOpen access · greenAbstract readClinical TrialLetter
In one paragraph
Trial report in The Journal of allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03444298 (A Phase II Randomized, Double Blinded, Placebo-controlled Study of Gamma Tocopherol-enriched Supplement on Lower Airway Responses to Inhaled Wood Smoke in Healthy Adults), which is not on this map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase II Randomized, Double Blinded, Placebo-controlled Study of Gamma Tocopherol-enriched Supplement on Lower Airway Responses to Inhaled Wood Smoke in Healthy Adults
Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Short course gamma tocopherol did not mitigate effects of ozone on airway inflammation in asthmatics.Inhalation toxicology · 2020Trial
- Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma.The Journal of allergy and clinical immunology · 2018Trial
- The effects of different forms of vitamin E on gut microbiota, mechanisms, and implications in disease prevention.The Journal of nutritional biochemistry · 2026Review
- Balancing the Cellular Inflammatory-Homeostatic Axis Through Natural Ingredient Supplementation.Nutrients · 2025Article
- The standardization and efficacy of fermentedOpen veterinary journal · 2024Article
- A pilot randomized clinical trial of γ-tocopherol supplementation on wood smoke-induced neutrophilic and eosinophilic airway inflammation.The journal of allergy and clinical immunology. Global · 2023Article
- The Role of Vitamins in the Pathogenesis of Asthma.International journal of molecular sciences · 2023Review
- Metabolism of natural forms of vitamin E and biological actions of vitamin E metabolites.Free radical biology & medicine · 2022Article
- Asthma, allergy and vitamin E: Current and future perspectives.Free radical biology & medicine · 2022Article
- Gamma-tocopherol, a major form of vitamin E in diets: Insights into antioxidant and anti-inflammatory effects, mechanisms, and roles in disease management.Free radical biology & medicine · 2022Article
- The effects of twenty-four nutrients and phytonutrients on immune system function and inflammation: A narrative review.Journal of clinical and translational research · 2021Review
- Utilization of redox modulating small molecules that selectively act as pro-oxidants in cancer cells to open a therapeutic window for improving cancer therapy.Redox biology · 2021Review
- Tocopherols and Tocotrienols Are Bioavailable in Rats and Primarily Excreted in Feces as the Intact Forms and 13'-Carboxychromanol Metabolites.The Journal of nutrition · 2020Article
- Delineation of the Individual Effects of Vitamin E Isoforms on Early Life Incident Wheezing.The Journal of pediatrics · 2019Article
- Circulating γ-Tocopherol Concentrations Are Inversely Associated with Antioxidant Exposures and Directly Associated with Systemic Oxidative Stress and Inflammation in Adults.The Journal of nutrition · 2018Article
- Update on Vitamin E and Its Potential Role in Preventing or Treating Bronchopulmonary Dysplasia.Neonatology · 2018Review
- Natural Forms of Vitamin E as Effective Agents for Cancer Prevention and Therapy.Advances in nutrition (Bethesda, Md.) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Allison J BurbankCenter for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of North Carolina, Chapel Hill, NC. Electronic address: allison_burbank@med.unc.edu.
Charity G DuranCenter for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC.
Martha AlmondCenter for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC.
Heather WellsCenter for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC.
Sha'Leema JenkinsCenter for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC.
Qing JiangDepartment of Nutrition Science, Purdue University, West Lafayette, Ind.
Chao YangDepartment of Nutrition Science, Purdue University, West Lafayette, Ind.
Ting WangDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.
Haibo ZhouDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.
Michelle L HernandezCenter for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of North Carolina, Chapel Hill, NC.
David B PedenCenter for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of North Carolina, Chapel Hill, NC.
University of North Carolina at Chapel Hill · USPurdue University West Lafayette · US
Funding
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MTOXICOLOGYT32ES007126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ILONA JASPERS, Bernard E. Weissman · 1985 to 2026
$13.0MUNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program-Evaluation SupplementT32GM086330 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KIM L.R. BROUWER, Daniel Gonzalez · 2011 to 2026
$8.5MPhase II studies of gamma tocopherol as an intervention for environmental asthmaR01ES023349 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PEDEN, DAVID B. · 2013 to 2017
$3.7MStatistical Methods for Outcome-Dependent SamplingR01ES021900 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZHOU, HAIBO · 2013 to 2016
$1.1MNIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES021900NIEHS NIH HHS R01 ES023349NIEHS NIH HHS T32 ES007126NIGMS NIH HHS T32 GM086330
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdultAnti-Inflammatory AgentsCytokinesDietary SupplementsFemalegamma-TocopherolHumansHypersensitivityInflammationLeukocytes, MononuclearLipopolysaccharidesMalePilot ProjectsYoung AdultAnti-Inflammatory AgentsCytokinesgamma-TocopherolLipopolysaccharides
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT03444298ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.