ArticleJournal of chromatography. A2017
Sweet spot matching: A thin-layer chromatography-based countercurrent solvent system selection strategy.
Article in Journal of chromatography. A, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
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- Chemical profiling and evaluation of in vitro antibacterial and antibiotic synergistic activities of Cleistanthus bracteosus Jabl. from Malaysian rainforests.BMC complementary medicine and therapies · 2026Article
- Sustainable and Scalable Enzymatic Production, Structural Elucidation, And Biological Evaluation of Novel Phlorizin Analogues.ChemSusChem · 2025Article
- Preparation, Modification, Quantitation, and Dentin Biomodification Activity of Selectively Enriched Proanthocyanidins.Journal of natural products · 2025Article
- Bioactivity-Guided High Performance Counter-Current Chromatography and Following Semi-Preparative Liquid Chromatography Method for Rapid Isolation of Anti-Inflammatory Lignins from Dai Medicinal Plant,Molecules (Basel, Switzerland) · 2023Article
- Antibacterial Activities of Monsonia Angustifolia and Momordica Balsamina Linn Extracts against Carbapenem-Resistant Acinetobacter Baumannii.Plants (Basel, Switzerland) · 2022Article
- Investigation of red clover (Trifolium pratense) isoflavonoid residual complexity by off-line CCS-qHNMR.Fitoterapia · 2022Article
- Antioxidant, antibacterial, antifungal activities and gas chromatographic fingerprint of fractions from the root bark ofInternational journal of biochemistry and molecular biology · 2022Article
- The Untargeted Capability of NMR Helps Recognizing Nefarious Adulteration in Natural Products.Journal of natural products · 2021Article
- Selective Chlorophyll Removal Method to "Degreen" Botanical Extracts.Journal of natural products · 2020Article
- Strategies in anti-Mycobacterium tuberculosis drug discovery based on phenotypic screening.The Journal of antibiotics · 2019Review
- Studying Mass Balance and the Stability of (Journal of natural products · 2019Article
- Selective Depletion and Enrichment of Constituents in "Curcumin" and Other Curcuma longa Preparations.Journal of natural products · 2019Article
- Evidence for Chemopreventive and Resilience Activity of Licorice:Cancer prevention research (Philadelphia, Pa.) · 2018Article
- Countercurrent separation assisted identification of two mammalian steroid hormones in Vitex negundo.Journal of chromatography. A · 2018Article
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Authors and funding
11 authors.
Funding
Abstract
TLC-based strategies were proposed in 1979 (Hostettmann et al.) and 2005 (Friesen & Pauli; GUESS method) to minimize the number of partitioning experiments required for countercurrent separation (CCS) solvent system selection. As semi-empirical approaches, both proposed that the K values defining the sweet spot of optimal CCS corresponded to a matching Rf value range from the silica gel TLC plate developed in the organic phase of a biphasic or a corresponding monophasic solvent system. Despite their simplicity, there has been an absence of theoretical support and a deficiency of reported experimental evidence. The present study explores the theory required to develop correlations between Rf and K. All theoretical models surmise that the optimal Rf value range should be centered at 0.5. In order to validate the feasibility of the concept of matching Rf and K values, 43 natural products and six solvent system families were investigated. Out of 62 correlations, 45 resulted in matched Rf and K values. Based on this study, practical guidelines for the TLC-based prediction strategy are provided. These approaches will equip CCS users with an updated understanding of how to apply the TLC-based solvent system selection strategy to accelerate a targeted selection of CCS conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.