Evidence map›Paper›PMID 28506443›Full record

ReviewCell calcium2018

Endoplasmic reticulum-resident selenoproteins as regulators of calcium signaling and homeostasis.

Matthew W Pitts, Peter R Hoffmann

Abstract readReview
In one paragraph

Review in Cell calcium, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
7.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 155 citations in OpenAlex.

  1. Review
  2. Article
  3. Selenium and Selenoproteins in Neutrophil Functions.Biological trace element research · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Selenoprotein K at the intersection of cellular pathways.Archives of biochemistry and biophysics · 2025
    Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Matthew W PittsDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
Peter R HoffmannDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA. Electronic address: peterrh@hawaii.edu.
University of Hawaiʻi at Mānoa · US

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI HELEN C TURNER · 2012 to 2026
$60.3M
The Role of gp120 on Cardiovascular Disease in People Living with HIVU54MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI Gehan Devendra · 2017 to 2026
$59.5M
TRPA1 Physiology in Diabetes, Metabolic Syndrome, and MetabolismP20GM113134 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Michael A. Ortega · 2017 to 2026
$21.5M
Selenoprotein K modulates calcium-dependent signaling in immune cellsR01AI089999 · NIAID · UNIVERSITY OF HAWAII AT MANOA · PI HOFFMANN, PETER R · 2010 to 2020
$3.6M
NIAID NIH HHS R01 AI089999NIGMS NIH HHS P20 GM103466NIGMS NIH HHS P20 GM113134NIMHD NIH HHS U54 MD007601
6 · The paper itself

Abstract

The human selenoprotein family contains 25 members that share the common feature of containing the amino acid, selenocysteine (Sec). Seven selenoproteins are localized to the endoplasmic reticulum (ER) and exhibit different structural features contributing to a range of cellular functions. Some of these functions are either directly or indirectly related to calcium (Ca

Indexed as

Calcium SignalingHomeostasisAnimalsEndoplasmic ReticulumEndoplasmic Reticulum StressHumansModels, BiologicalSelenoproteinsSelenoproteinsChaperoneER stressInositol 1,4,5-triphosphate receptorProtein foldingSeleniumSERCA pump

Identifiers

PMID28506443
PMCPMC5671369
OpenAlexW2610443858

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.