Evidence map›Paper›PMID 28506365›Full record

ReviewGastroenterology clinics of North America2017

Drug-induced Liver Injury: The Hepatic Pathologist's Approach.

David E Kleiner

Abstract readReview
In one paragraph

Review in Gastroenterology clinics of North America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Evidence for preventing EVRB in cirrhotic patients: A systematic review.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2025
    Pooled it
  2. Review
  3. Acute immune-mediated hepatocellular injury temporally associated with romosozumab: a probable autoimmune-like drug-induced liver injury.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  4. Review
  5. Clinico-pathologic correlation in ocular sarcoidosis.American journal of ophthalmology case reports · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Observational
  12. Article
  13. Article
  14. Article
  15. Combinatorial Herbal Extracts Alleviate Alcohol-Induced Hepatic Disorders.Plant foods for human nutrition (Dordrecht, Netherlands) · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

David E KleinerLaboratory of Pathology, National Cancer Institute, 10 Center Drive, Building 10, Room 2S235, MSC 1500, Bethesda, MD 20892, USA. Electronic address: kleinerd@mail.nih.gov.

Funding

Postmortem PathologyZICBC010685 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KLEINER, DAVID ERWIN · 2009 to 2025
$14.3M
Postmortem PathologyZ01BC010685 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KLEINER, DAVID E · 2005 to 2008
$913k
Intramural NIH HHS Z01 BC010685
6 · The paper itself

Abstract

The evaluation of liver biopsies in suspected drug-induced liver injury (DILI) can be complex. The biopsy may be approached systematically, by identification of histologic lesions and then identification of the overall pattern of injury. Potential DILI must be separated from concomitant non-DILI liver disease. The findings can be analyzed with respect to the various prescription and nonprescription medications and dietary supplements under suspicion to provide a complete interpretation of the findings. The pathologic findings, the histologic differential diagnosis, and expert interpretation are part of a complete biopsy assessment and provide information that is of greatest value in patient management.

Indexed as

BiopsyChemical and Drug Induced Liver InjuryDiagnosis, DifferentialHepatitis, Viral, HumanHumansLiverNon-alcoholic Fatty Liver DiseaseAcute hepatitisAcute liver failureCholestasisHepatic necrosisHepatotoxicity

Identifiers

PMID28506365
PMCPMC5434713

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.