Evidence map›Paper›PMID 28505377›Full record

ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2018

Performance of glomerular filtration rate estimating equations in a community-based sample of Blacks and Whites: the multiethnic study of atherosclerosis.

Lesley A Inker, Andrew S Levey, Hocine Tighiouart, Tariq Shafi, John H Eckfeldt, Craig Johnson, Aghogho Okparavero, Wendy S Post, Josef Coresh, Michael G Shlipak

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In one paragraph

Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  17. Providing Care for Transgender Persons With Kidney Disease: A Narrative Review.Canadian journal of kidney health and disease · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lesley A InkerDivision of Nephrology, Tufts Medical Center, Boston, MA, USA.
Andrew S LeveyDivision of Nephrology, Tufts Medical Center, Boston, MA, USA.
Hocine TighiouartInstitute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA.
Tariq ShafiJohns Hopkins University, Baltimore, MD, USA.
John H EckfeldtDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Craig JohnsonDepartment of Biostatistics, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA.
Aghogho OkparaveroDivision of Nephrology, Tufts Medical Center, Boston, MA, USA.
Wendy S PostJohns Hopkins University, Baltimore, MD, USA.
Josef CoreshJohns Hopkins University, Baltimore, MD, USA.
Michael G ShlipakDivision of Nephrology, University of California, San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations are recommended for glomerular filtration rate (GFR) estimation in the general population. They have not been evaluated in community-based populations, including Blacks at higher levels of GFR, but are commonly applied in such populations. Methods: In an ancillary study of Multi-Ethnic Study of Atherosclerosis conducted at one site, we evaluated the performance of the CKD-EPI equations for creatinine (eGFRcr), cystatin C (eGFRcys) or the combination (eGFRcr-cys) compared with GFR measured as plasma clearance of iohexol. Results: Among 294 participants, the mean age was 71 (SD 9) years, 47% were Black, 48% were women and the mean measured GFR (mGFR) was 72.6 (SD 18.8) mL/min/1.73 m2. The CKD-EPI equations overestimated mGFR with a larger median bias for eGFRcr and eGFRcr-cys than eGFRcys [-8.3 (95% confidence interval -9.7, -6.5), -7.8 (-9.2, -6.2) and -3.7 (-5.0, -1.8) mL/min/1.73 m2, respectively], with smaller bias for those with lower compared with higher eGFR and by race compared with sex. Conclusion: The small differential bias of the CKD-EPI equation between races suggests that they can be used in Blacks as well as Whites in older community-based adults. The large differential bias in women versus men in all equations is in contrast to other studies and is unexplained. Further studies are required in multiracial and multiethnic community-based cohorts, taking into account differences in GFR measurement methods.

Indexed as

AlgorithmsGlomerular Filtration RateAdultAgedAtherosclerosisBlack PeopleCreatinineCystatin CEthnicityFemaleHumansMaleMiddle AgedPredictive Value of TestsRenal Insufficiency, ChronicWhite PeopleCreatinineCystatin C

Identifiers

PMID28505377
PMCPMC6018782

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.