ArticlePLoS neglected tropical diseases2017
Lp25 membrane protein from pathogenic Leptospira spp. is associated with rhabdomyolysis and oliguric acute kidney injury in a guinea pig model of leptospirosis.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- A case of severe leptospirosis complicated with massive rhabdomyolysis and acute kidney injury: a case report.Journal of medical case reports · 2025Article
- Non-purulent myositis caused by direct invasion of skeletal muscle tissue byInfection and immunity · 2024Article
- Clinical outcomes of rhabdomyolysis & validation of McMahon Score for risk prediction.The Indian journal of medical research · 2024Article
- Authors' Reply: Rhabdomyolysis-Induced Acute Kidney Injury in Austere Environments Highlights Need for Specific Treatment.Kidney international reports · 2023Article
- Interesting Histology in Tropical Acute Kidney Injury.Kidney international reports · 2023Article
- GroEL protein of the Leptospira spp. interacts with host proteins and induces cytokines secretion on macrophages.BMC microbiology · 2021Article
- Detection ofVeterinary world · 2020Article
- Immunohistochemical detection of Lp25 and LipL32 proteins in skeletal and cardiac muscles of fatal human leptospirosis.Revista do Instituto de Medicina Tropical de Sao Paulo · 2020Article
- Role of Supramolecule ErpY-Like Lipoprotein ofInfection and immunity · 2019Article
- Pigment Nephropathy: Novel Insights into Inflammasome-Mediated Pathogenesis.International journal of molecular sciences · 2019Review
- Role of Murine Complement Component C5 in AcuteFrontiers in cellular and infection microbiology · 2018Article
- Pathology and pathogenesis of human leptospirosis: a commented review.Revista do Instituto de Medicina Tropical de Sao Paulo · 2018Review
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) from leptospirosis is frequently nonoliguric with hypo- or normokalemia. Higher serum potassium levels are observed in non-survivor patients and may have been caused by more severe AKI, metabolic disarrangement, or rhabdomyolysis. An association between the creatine phosphokinase (CPK) level and maximum serum creatinine level has been observed in these patients, which suggests that rhabdomyolysis contributes to severe AKI and hyperkalemia. LipL32 and Lp25 are conserved proteins in pathogenic strains of Leptospira spp., but these proteins have no known function. This study evaluated the effect of these proteins on renal function in guinea pigs. Lp25 is an outer membrane protein that appears responsible for the development of oliguric AKI associated with hyperkalemia induced by rhabdomyolysis (e.g., elevated CPK, uric acid and serum phosphate). This study is the first characterization of a leptospiral outer membrane protein that is associated with severe manifestations of leptospirosis. Therapeutic methods to attenuate this protein and inhibit rhabdomyolysis-induced AKI could protect animals and patients from severe forms of this disease and decrease mortality.
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