ArticlePLoS neglected tropical diseases2017
Rapid deployment of a mobile biosafety level-3 laboratory in Sierra Leone during the 2014 Ebola virus epidemic.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Ebola virus disease: A persistent challenge in global health security.Open veterinary journal · 2026Review
- Validation of a mobile clinical pathology laboratory for canine hematology and biochemistry.BMC veterinary research · 2025Article
- China-UK Global Health Collaboration Project on Strengthening Public Health Capacity in Sierra Leone.China CDC weekly · 2025Article
- Existing operational standards for field deployments of rapid response mobile laboratories: a scoping review.Frontiers in public health · 2024Article
- An airlock concept to reduce contamination risks during the human exploration of Mars.NPJ microgravity · 2023Article
- Build a Sustainable Vaccines Industry with Synthetic Biology.Trends in biotechnology · 2021Review
- Biodefence research two decades on: worth the investment?The Lancet. Infectious diseases · 2021Review
- How To Prepare for the Unexpected: a Public Health Laboratory Response.Clinical microbiology reviews · 2021Review
- A Highly Automated Mobile Laboratory for On-site Molecular Diagnostics in the COVID-19 Pandemic.Clinical chemistry · 2021Article
- Practice in Information Technology Support for Fangcang Shelter Hospital during COVID-19 Epidemic in Wuhan, China.Journal of medical systems · 2021Article
- Risk of Environmental Exposure to H7N9 Influenza VirusFrontiers in cellular and infection microbiology · 2021Article
- Screening High-Risk Groups and the General Population for SARS-CoV-2 Nucleic Acids in a Mobile Biosafety Laboratory.Frontiers in public health · 2021Article
- The deployment of mobile diagnostic laboratories for Ebola virus disease diagnostics in Sierra Leone and Guinea.African journal of laboratory medicine · 2021Article
- COVID-19: Postmortem Diagnostic and Biosafety Considerations.The American journal of forensic medicine and pathology · 2020Article
- Aerosol and Surface Distribution of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospital Wards, Wuhan, China, 2020.Emerging infectious diseases · 2020Article
- Field evaluation of a mobile biosafety laboratory in Senegal to strengthen rapid disease outbreak response and monitoring.African journal of laboratory medicine · 2020Article
- Developments in Transduction, Connectivity and AI/Machine Learning for Point-of-Care Testing.Sensors (Basel, Switzerland) · 2019Article
- Mobile High-Containment Biological Laboratories Deployment: Opportunities and Challenges in Expeditionary Deployments to Outbreak Response.Applied biosafety : journal of the American Biological Safety Association · 2019Article
- Challenges and perspectives on the use of mobile laboratories during outbreaks and their use for vaccine evaluation.Human vaccines & immunotherapeutics · 2019Article
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Authors and funding
25 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundEbola virus emerged in West Africa in December 2013. The high population mobility and poor public health infrastructure in this region led to the development of the largest Ebola virus disease (EVD) outbreak to date. METHODOLOGY/PRINCIPAL
findingsOn September 26, 2014, China dispatched a Mobile Biosafety Level-3 Laboratory (MBSL-3 Lab) and a well-trained diagnostic team to Sierra Leone to assist in EVD diagnosis using quantitative real-time PCR, which allowed the diagnosis of suspected EVD cases in less than 4 hours from the time of sample receiving. This laboratory was composed of three container vehicles equipped with advanced ventilation system, communication system, electricity and gas supply system. We strictly applied multiple safety precautions to reduce exposure risks. Personnel, materials, water and air flow management were the key elements of the biosafety measures in the MBSL-3 Lab. Air samples were regularly collected from the MBSL-3 Lab, but no evidence of Ebola virus infectious aerosols was detected. Potentially contaminated objects were also tested by collecting swabs. On one occasion, a pipette tested positive for EVD. A total of 1,635 suspected EVD cases (824 positive [50.4%]) were tested from September 28 to November 11, 2014, and no member of the diagnostic team was infected with Ebola virus or other pathogens, including Lassa fever. The specimens tested included blood (69.2%) and oral swabs (30.8%) with positivity rates of 54.2% and 41.9%, respectively. The China mobile laboratory was thus instrumental in the EVD outbreak response by providing timely and reliable diagnostics. CONCLUSIONS/SIGNIFICANCE: The MBSL-3 Lab significantly contributed to establishing a suitable laboratory response capacity during the emergence of EVD in Sierra Leone.
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