Evidence map›Paper›PMID 28504928›Full record

ArticleeLife2017

The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells.

Christopher L Cunningham, Zizhen Wu, Aria Jafari, Bo Zhao, Kat Schrode, Sarah Harkins-Perry, Amanda Lauer, Ulrich Müller

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. Inhibition of GABARAP or GABARAPL1 prevents aminoglycoside- induced hearing loss.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Transmembrane Channel-Like (Tmc) Subunits Contribute to Frequency Sensitivity in the Zebrafish Utricle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Mechanotransduction in mammalian sensory hair cells.Molecular and cellular neurosciences · 2022
    Review
  11. Article
  12. Review
  13. Article
  14. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  15. Article
  16. Article
  17. Distinct functions of TMC channels: a comparative overview.Cellular and molecular life sciences : CMLS · 2019
    Review
  18. Function and Dysfunction of TMC Channels in Inner Ear Hair Cells.Cold Spring Harbor perspectives in medicine · 2019
    Review
  19. Molecular Structure of the Hair Cell Mechanoelectrical Transduction Complex.Cold Spring Harbor perspectives in medicine · 2019
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Christopher L CunninghamThe Solomon Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, United States.ORCID 0000-0002-9619-4190
Zizhen WuThe Solomon Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, United States.
Aria JafariDepartment of Surgery, University of California, San Diego, San Diego, United States.
Bo ZhaoDepartment of Otolaryngology Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, United States.
Kat SchrodeDepartment of Otolaryngology, Johns Hopkins University, Baltimore, United States.
Sarah Harkins-PerryDepartment of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, United States.
Amanda LauerDepartment of Otolaryngology, Johns Hopkins University, Baltimore, United States.ORCID 0000-0003-4184-7374
Ulrich MüllerThe Solomon Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, United States.ORCID 0000-0003-2736-6494
Johns Hopkins University · USIndiana University School of MedicineScripps Research Institute · USUniversity of California San Diego · US

Funding

Mechanosensor Development, Function, and DysfunctionR01DC005965 · NIDCD · SCRIPPS RESEARCH INSTITUTE, THE · PI MUELLER, ULRICH · 2003 to 2023
$10.2M
The Histology CoreP30DC005211 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI YOUNG, ERIC DANIEL · 2002 to 2016
$9.1M
Training Program in Hearing and BalanceT32DC000023 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI CULLEN, KATHLEEN E · 1989 to 2025
$8.7M
Contribution of COMT2 to auditory processing in mammalian sensory hair cellsF32DC015724 · NIDCD · SCRIPPS RESEARCH INSTITUTE, THE · PI CUNNINGHAM, CHRISTOPHER L · 2016 to 2018
$184k
NIDCD NIH HHS F32 DC015724NIDCD NIH HHS P30 DC005211NIDCD NIH HHS R01 DC005965NIDCD NIH HHS T32 DC000023
6 · The paper itself

Abstract

Hair cells of the cochlea are mechanosensors for the perception of sound. Mutations in the

Indexed as

Catechol O-MethyltransferaseMechanotransduction, CellularAnimalsCatecholaminesHair Cells, AuditoryMethylationMiceCatecholaminesCatechol O-Methyltransferasehair cellhearingmechanotransductionneurosciencenonestereociliaTomt

Identifiers

PMID28504928
PMCPMC5462538
OpenAlexW2613088066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.