Evidence map›Paper›PMID 28504795›Full record

ArticleThe Analyst2017

Label-free detection of DNA hybridization with a compact LSPR-based fiber-optic sensor.

Savannah Kaye, Zheng Zeng, Mollye Sanders, Krishnan Chittur, Paula M Koelle, Robert Lindquist, Upender Manne, Yongbin Lin, Jianjun Wei

Open access · greenAbstract read
In one paragraph

Article in The Analyst, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Savannah KayeCenter for Applied Optics, University of Alabama at Huntsville, Huntsville, AL 35899, USA. liny@uah.edu.
Zheng ZengDepartment of Nanoscience, Joint School of Nanoscience and Nanoengineering, University of North Carolina at Greensboro, Greensboro, NC 27401, USA. j_wei@uncg.edu.
Mollye SandersCenter for Applied Optics, University of Alabama at Huntsville, Huntsville, AL 35899, USA. liny@uah.edu.
Krishnan ChitturChemical and Materials Engineering, University of Alabama Huntsville, Huntsville, AL 35899, USA and Genecapture, 601 Genome Way, Huntsville, AL 35806, USA.
Paula M KoelleGenecapture, 601 Genome Way, Huntsville, AL 35806, USA.
Robert LindquistCenter for Applied Optics, University of Alabama at Huntsville, Huntsville, AL 35899, USA. liny@uah.edu.
Upender ManneDepartment of Pathology, University of Alabama at Birmingham, AL 35249, USA.
Yongbin LinCenter for Applied Optics, University of Alabama at Huntsville, Huntsville, AL 35899, USA. liny@uah.edu.
Jianjun WeiDepartment of Nanoscience, Joint School of Nanoscience and Nanoengineering, University of North Carolina at Greensboro, Greensboro, NC 27401, USA. j_wei@uncg.edu.ORCID http://orcid.org/0000-0002-2658-0248
Huntsville Hospital · USUniversity of North Carolina at Greensboro · USUniversity of Alabama at Birmingham · US

Funding

TRAINING AND CAREER DEVELOPMENTU54CA118948 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI UPENDER MANNE · 2005 to 2026
$26.6M
Training and Education ProgramP20CA192973 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MANNE, UPENDER · 2014 to 2017
$767k
NCI NIH HHS P20 CA192973NCI NIH HHS U54 CA118948
6 · The paper itself

Abstract

A miniaturized, robust, localized surface plasmon resonance (LSPR)-coupled fiber-optic (FO) nanoprobe providing an integrated and portable solution for detection of DNA hybridization and measurement of DNA concentrations has been demonstrated. The FO nanoprobe was created by constructing arrays of metallic nanostructures on the end facets of optical fibers utilizing nanofabrication technologies, including electron beam lithography and lift-off processes. The LSPR-FO nanoprobe device offers real-time, label-free, and low-sample-volume quantification of single-strand DNA in water with high sensitivity and selectivity, achieving a limit of detection around 10 fM. These results demonstrate the feasibility of the LSPR-FO nanoprobe device as a compact and low-cost biosensor for detection of short-strand DNA.

Indexed as

Biosensing TechniquesFiber Optic TechnologyNanostructuresSurface Plasmon ResonanceDNAOptical FibersDNA

Identifiers

PMID28504795
PMCPMC5714651
OpenAlexW2607587872

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.