ArticleMolecular and cellular biology1988
Small gene family encoding an eggshell (chorion) protein of the human parasite Schistosoma mansoni.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 64 citations in OpenAlex.
- Comparative Transcriptome Analyses ofFrontiers in microbiology · 2020Article
- In vitro activity of aryl-thiazole derivatives against Schistosoma mansoni schistosomula and adult worms.PloS one · 2019Article
- Identification of new markers for the Schistosoma mansoni vitelline lineage.International journal for parasitology · 2016Article
- Genomic linkage map of the human blood fluke Schistosoma mansoni.Genome biology · 2009Article
- Isolation of cDNAs encoding secreted and transmembrane proteins from Schistosoma mansoni by a signal sequence trap method.Infection and immunity · 2003Article
- Identification of Schistosoma mansoni gender-associated gene transcripts by cDNA microarray profiling.Genome biology · 2002Article
- A potential mediator of collagenous block copolymer gradients in mussel byssal threads.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- A cloned major Schistosoma mansoni egg antigen with homologies to small heat shock proteins elicits Th1 responsiveness.Infection and immunity · 1996Article
- Three copies of the early gene 6F6 are interspersed in and around the late chorion gene cluster of Bombyx mori.Journal of molecular evolution · 1992Article
- A spliced leader is present on a subset of mRNAs from the human parasite Schistosoma mansoni.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have isolated six independent genomic clones encoding schistosome chorion or eggshell proteins from a Schistosoma mansoni genomic library. A linkage may of five of the clones spanning 35 kilobase pair (kbp) of the S. mansoni genome was constructed. The region contained two eggshell protein genes closely linked, separated by 7.5 kbp of intergenic DNA. The two genes of the cluster were arranged in the same orientation, that is, they were transcribed from the same strand. The sixth clone probably represents a third copy of the eggshell gene that is not contained within the 35-kbp region. The 5' end of the mRNA transcribed from these genes was defined by primer extension directly off the RNA. The ATCAT cap site sequence was homologous to a silkmoth chorion PuTCATT cap site sequence, where Pu indicates any purine. DNA sequence analysis showed that there were no introns in these genes. The DNA sequences of the three genes were very homologous to each other and to a cDNA clone, pSMf61-46, differing only in three or four nucleotides. A multiple TATA box was located at positions -23 to -31, and a CAAAT sequence was located at -52 upstream of the eggshell transcription unit. Comparison of sequences in regions further upstream with silkmoth and Drosophila sequences revealed several very short elements that were shared. One such element, TCACGT, recently shown to be an essential cis-regulatory element for silkmoth chorion gene promoter function, was found at a similar position in all three organisms.
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