Evidence map›Paper›PMID 28504696›Full record

ArticleNature structural & molecular biology2017

5-Formylcytosine does not change the global structure of DNA.

Jack S Hardwick, Denis Ptchelkine, Afaf H El-Sagheer, Ian Tear, Daniel Singleton, Simon E V Phillips, Andrew N Lane, Tom Brown

Abstract read
In one paragraph

Article in Nature structural & molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. NMR-Based Stable Isotope Tracing of Cancer Metabolism.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  3. Article
  4. Review
  5. ACS physical chemistry Au · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Comparative Nucleosomal Reactivity of 5-Formyl-Uridine and 5-Formyl-Cytidine.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Article
  10. Chiral Systems Made from DNA.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Comparison of DNA and RNA substrate effects on TET2 structure.Advances in protein chemistry and structural biology · 2019
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jack S HardwickDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Oxford, UK.ORCID http://orcid.org/0000-0002-3117-1035
Denis PtchelkineResearch Complex at Harwell, Rutherford Appleton Laboratory, Didcot, UK.
Afaf H El-SagheerDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Oxford, UK.
Ian TearATDBio, School of Chemistry, University of Southampton, Southampton, UK.
Daniel SingletonATDBio, School of Chemistry, University of Southampton, Southampton, UK.
Simon E V PhillipsResearch Complex at Harwell, Rutherford Appleton Laboratory, Didcot, UK.ORCID http://orcid.org/0000-0001-8922-0250
Andrew N LaneDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky, USA.
Tom BrownDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Oxford, UK.ORCID http://orcid.org/0000-0002-6538-3036

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI KATHLEEN L. O'CONNOR · 2013 to 2026
$38.3M
SAMPLE COREU24DK097215 · NIDDK · UNIVERSITY OF KENTUCKY · PI FAN, TERESA WHEI-MEI, HIGASHI, RICHARD M · 2013 to 2017
$8.7M
Medical Research Council MC_EX_G0901251NCI NIH HHS P30 CA177558NIDDK NIH HHS U24 DK097215
6 · The paper itself

Abstract

The mechanism by which the recently identified DNA modification 5-formylcytosine (

Indexed as

Nucleic Acid ConformationCrystallography, X-RayCytosineDNAMagnetic Resonance Spectroscopy5-formylcytosineCytosineDNA

Identifiers

PMID28504696
PMCPMC5747368

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.