Evidence map›Paper›PMID 28504638›Full record

ArticleeLife2017

Catecholaminergic challenge uncovers distinct Pavlovian and instrumental mechanisms of motivated (in)action.

Jennifer C Swart, Monja I Froböse, Jennifer L Cook, Dirk Em Geurts, Michael J Frank, Roshan Cools, Hanneke Em den Ouden

Registry-linked trialAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06027723 (Effects of Acute Nicotine Administration on Motivational Mechanisms), which is not on this map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06027723 early_phase1unknown statusnot on this mapstarted 2023, after this paper: background citation

Effects of Acute Nicotine Administration on Motivational Mechanisms

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2023 to 2024Enrolled40ConditionsNicotine Vaping, Nicotine DependenceArmsNicotine, Placebo
3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jennifer C SwartDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.ORCID 0000-0003-0989-332X
Monja I FroböseDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Jennifer L CookDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Dirk Em GeurtsDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.ORCID 0000-0002-2505-1301
Michael J FrankDepartment of Cognitive, Linguistic and Psychological Sciences, Brown University, Providence, United States.ORCID 0000-0001-8451-0523
Roshan CoolsDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Hanneke Em den OudenDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.

Funding

Clinical and Computational Studies of Dopamine Function in SchizophreniaR01MH080066 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI GOLD, JAMES M. · 2008 to 2017
$6.4M
NIMH NIH HHS R01 MH080066
6 · The paper itself

Abstract

Catecholamines modulate the impact of motivational cues on action. Such motivational biases have been proposed to reflect cue-based, 'Pavlovian' effects. Here, we assess whether motivational biases may also arise from asymmetrical instrumental

Indexed as

AdolescentAdultConditioning, ClassicalConditioning, OperantCuesFemaleHumansMaleMethylphenidateModels, NeurologicalMotivationNetherlandsVolunteersYoung AdultMethylphenidatedopaminehumanlearningmotivational biasesneuroscience

Identifiers

PMID28504638
PMCPMC5432212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.