Evidence map›Paper›PMID 28504306›Full record

ArticleFEBS letters2017

Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn

Elizabeth Ransey, Eduardo Paredes, Sourav K Dey, Subha R Das, Annie Heroux, Mark R Macbeth

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Life and Death of mRNA Molecules inFrontiers in cellular and infection microbiology · 2018
    Review
  6. Unexplored Molecular Features of theFrontiers in cellular and infection microbiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Elizabeth RanseyDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Eduardo ParedesDepartment of Chemistry and Center for Nucleic Acids & Technology, Carnegie Mellon University, Pittsburgh, PA, USA.
Sourav K DeyDepartment of Chemistry and Center for Nucleic Acids & Technology, Carnegie Mellon University, Pittsburgh, PA, USA.
Subha R DasDepartment of Chemistry and Center for Nucleic Acids & Technology, Carnegie Mellon University, Pittsburgh, PA, USA.
Annie HerouxNational Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY, USA.
Mark R MacbethDepartment of Chemistry and Biochemistry, Butler University, Indianapolis, IN, USA.
Carnegie Mellon University · USBrookhaven National Laboratory · USButler University · USHarvard University · US

Funding

Molecular Dissection of Debranching EnzymeR01GM110414 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI DAS, SUBHA RANJAN · 2014 to 2017
$1.1M
NIGMS NIH HHS R01 GM110414
6 · The paper itself

Abstract

The RNA lariat debranching enzyme, Dbr1, is a metallophosphoesterase that cleaves 2'-5' phosphodiester bonds within intronic lariats. Previous reports have indicated that Dbr1 enzymatic activity is supported by diverse metal ions including Ni

Indexed as

BiocatalysisCatalytic DomainCrystallography, X-RayEntamoeba histolyticaManganeseModels, MolecularRNA NucleotidyltransferasesZinclariat debranching enzymeManganeseRNA NucleotidyltransferasesZincheterobinucleationICP-AESmetallophosphoesterase

Identifiers

PMID28504306
PMCPMC5733776
OpenAlexW2615492919

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.