ArticleNature communications2017
Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins.
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In one paragraph
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- SIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Article
- SIRT1/PGC-1α/Mfn2 pathway regulates mitochondrial homeostasis in VSMC to attenuate aging-related vascular calcification.Scientific reports · 2025Article
- Traversing the epigenetic landscape: DNA methylation from retina to brain in development and disease.Frontiers in cellular neuroscience · 2024Review
- Total coumarins of Pileostegia tomentella induces cell death in SCLC by reprogramming metabolic patterns, possibly through attenuating β-catenin/AMPK/SIRT1.Chinese medicine · 2023Article
- ImitateDB: A database for domain and motif mimicry incorporating host and pathogen protein interactions.Amino acids · 2022Article
- Targeting NAD+: is it a common strategy to delay heart aging?Cell death discovery · 2022Review
- Panax notoginseng saponins reverse P-gp-mediated steroid resistance in lupus: involvement in the suppression of the SIRT1/FoxO1/MDR1 signalling pathway in lymphocytes.BMC complementary medicine and therapies · 2022Article
- Moderate SIRT1 overexpression protects against brown adipose tissue inflammation.Molecular metabolism · 2020Article
- Illuminating NADDevelopmental cell · 2020Article
- The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy.Frontiers in cell and developmental biology · 2020Review
- Bax expression is optimal at low oxygen tension and constant agitation.Protein expression and purification · 2020Article
- Updates on the epigenetic roles of sirtuins.Current opinion in chemical biology · 2019Review
- Prenatal epigenetics diets play protective roles against environmental pollution.Clinical epigenetics · 2019Review
- Characterization of SIRT1/DNMTs Functions and LINE-1 Methylation in Patients with Age-Related Macular Degeneration.Journal of clinical medicine · 2019Article
- Resveratrol Modulates SIRT1 and DNMT Functions and Restores LINE-1 Methylation Levels in ARPE-19 Cells under Oxidative Stress and Inflammation.International journal of molecular sciences · 2018Article
- SIRT1 Activation by Resveratrol Alleviates Cardiac Dysfunction via Mitochondrial Regulation in Diabetic Cardiomyopathy Mice.Oxidative medicine and cellular longevity · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 5 institutions in 2 countries.
Hyeog KangLaboratory of Obesity and Aging Research, Genetics and Development Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Shinichi OkaDepartment of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers University, New Jersey Medical School, Newark, New Jersey 07101, USA.
Duck-Yeon LeeBiochemistry Core Facility, Biochemistry and Biophysics Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Junhong ParkTulane University School of Medicine, Department of Pathology, New Orleans, Louisiana 70112, USA.
Angel M AponteProteomics Core Facility, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Young-Sang JungIntegrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute, Seoul 120-140, Republic of Korea.
Jacob BittermanLaboratory of Obesity and Aging Research, Genetics and Development Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Peiyong ZhaiDepartment of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers University, New Jersey Medical School, Newark, New Jersey 07101, USA.
Yi HeLaboratory of Molecular Biophysics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Hamed KooshapurLaboratory of Molecular Biophysics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Rodolfo GhirlandoLaboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Nico TjandraLaboratory of Molecular Biophysics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Sean B LeeTulane University School of Medicine, Department of Pathology, New Orleans, Louisiana 70112, USA.
Myung K KimLaboratory of Obesity and Aging Research, Genetics and Development Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Junichi SadoshimaDepartment of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers University, New Jersey Medical School, Newark, New Jersey 07101, USA.
Jay H ChungLaboratory of Obesity and Aging Research, Genetics and Development Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
National Heart Lung and Blood Institute · USNational Institutes of Health · USRutgers, The State University of New Jersey · USTulane University · USKorea Basic Science Institute · KR
Funding
NHLBI Animal Program DivisionZIGHL006020 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI CLARK, TANNIA · 2009 to 2025
$47.3MNmr Studies Of The Regulation Of Cell SignalingZIAHL001048 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI TJANDRA, NICO · 2009 to 2025
$20.1MTreatment for obesityZIAHL006118 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI CHUNG, JAY H · 2011 to 2019
$11.2MBiophysics of Macromolecular ComplexesZIADK033007 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI BUCHANAN, SUSAN · 2009 to 2024
$4.9MBiochemistry CoreZICHL006227 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEE, DUCK-YEON · 2017 to 2025
$4.6MAbstract
Sirt1 is an NAD
Indexed as
Adenosine TriphosphateAdipogenesisAnimalsBinding SitesDeoxyglucoseGene Expression RegulationHEK293 CellsHumansMaleMiceMutationPlasmidsProtein DomainsSirtuin 1Transcription FactorsAdenosine TriphosphateDeoxyglucoseSIRT1 protein, humanSirt1 protein, mouseSirtuin 1Transcription Factors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.