ArticleBioethics2017
The Ethics of Clinical Trials Research in Severe Mood Disorders.
Article in Bioethics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Ethical challenges researchers encounter during the informed consent processes for research involving people with schizophrenia and bipolar affective disorder: a qualitative assessment.BMC medical ethics · 2026Article
- Off-label Prescribing of Clozapine and Safety.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2025Review
- Decision-making and performance in the Iowa Gambling Task: recent ERP findings and clinical implications.Frontiers in psychology · 2025Review
- Ethics Guideline Development for Neuroscience Research involving Patients with Mental Illness in Japan.Asian bioethics review · 2023Article
- Hydroxychloroquine and COVID-19: critiquing the impact of disease public profile on policy and clinical decision-making.Journal of medical ethics · 2020Article
- Decisional Capacity for Informed Consent in Males and Females with Fragile X Syndrome.Journal of autism and developmental disorders · 2020Article
- Carers' Motivations for, and Experiences of, Participating in Suicide Research.International journal of environmental research and public health · 2020Article
- Negative association of perceived risk and willingness to participate in innovative psychiatric research protocols.Journal of psychiatric research · 2020Article
- Research on the pathophysiology, treatment, and prevention of suicide: practical and ethical issues.BMC psychiatry · 2019Article
- Expanding Access to Cancer Clinical Trials for Patients With Mental Illness.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2019Article
- Neurobiological research with suicidal participants: A framework for investigators.General hospital psychiatryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD), are highly prevalent, frequently disabling, and sometimes deadly. Additional research and more effective medications are desperately needed, but clinical trials research in mood disorders is fraught with ethical issues. Although many authors have discussed these issues, most do so from a theoretical viewpoint. This manuscript uses available empirical data to inform a discussion of the primary ethical issues raised in mood disorders research. These include issues of consent and decision-making capacity, including patients' motivations for participating in research. We also address drug withdrawals, placebo controls, and the overall safety of research. Finally, we examine the extant literature for studies discussing potential indirect benefits of clinical trials research to participants. Taken together, the evidence suggests that clinical trials research incorporating drug withdrawals and placebo controls can be conducted safely and ethically, even in patients with severe or treatment-resistant mood disorders. In fact, given the dearth of effective treatment options for this population, it is our opinion that a moral imperative exists to extend the offer of research participation to severely ill or treatment-resistant groups.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.