Evidence map›Paper›PMID 28503676›Full record

ArticleProceedings. IEEE International Conference on Healthcare Informatics2016

Learning Optimal Individualized Treatment Rules from Electronic Health Record Data.

Yuanjia Wang, Peng Wu, Ying Liu, Chunhua Weng, Donglin Zeng

Abstract read
In one paragraph

Article in Proceedings. IEEE International Conference on Healthcare Informatics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Learning Personalized Treatment Rules from Electronic Health Records Using Topic Modeling Feature Extraction.Proceedings of the ... International Conference on Data Science and Advanced Analytics. IEEE International Conference on Data Science and Advanced Analytics · 2019
    Article
  5. Precision Medicine.Annual review of statistics and its application · 2019
    Article
  6. Deep Reinforcement Learning for Dynamic Treatment Regimes on Medical Registry Data.Healthcare informatics : the business magazine for information and communication systems · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuanjia WangDepartment of Biostatistics, Columbia University.
Peng WuDepartment of Biostatistics, Columbia University.
Ying LiuDepartment of Biostatistics, Columbia University.
Chunhua WengDepartment of Biomedical Informatics, Columbia University.
Donglin ZengDepartment of Biostatistics, University at North Carolina at Chapel Hill.

Funding

Statistical Methods for Cancer Clinical TrialsP01CA142538 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVIDIAN, MARIE, KOSOROK, MICHAEL R · 2010 to 2019
$21.3M
Statistical Methods for Integrating Mixed-type Biomarkers and Phenotypes in Neurodegenerative Disease ModelingR01NS073671 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WANG, YUANJIA · 2011 to 2025
$3.9M
Identifying Huntington's disease markers by modern statistical learning methods.U01NS082062 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WANG, YUANJIA · 2014 to 2016
$1.1M
NCI NIH HHS P01 CA142538NINDS NIH HHS R01 NS073671NINDS NIH HHS U01 NS082062
6 · The paper itself

Abstract

Medical research is experiencing a paradigm shift from "one-size-fits-all" strategy to a precision medicine approach where the right therapy, for the right patient, and at the right time, will be prescribed. We propose a statistical method to estimate the optimal individualized treatment rules (ITRs) that are tailored according to subject-specific features using electronic health records (EHR) data. Our approach merges statistical modeling and medical domain knowledge with machine learning algorithms to assist personalized medical decision making using EHR. We transform the estimation of optimal ITR into a classification problem and account for the non-experimental features of the EHR data and confounding by clinical indication. We create a broad range of feature variables that reflect both patient health status and healthcare data collection process. Using EHR data collected at Columbia University clinical data warehouse, we construct a decision tree for choosing the best second line therapy for treating type 2 diabetes patients.

Identifiers

PMID28503676
PMCPMC5423731

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.