Evidence map›Paper›PMID 28503662›Full record

ArticleBioengineering & translational medicine2017

Picoliter-volume inkjet printing into planar microdevice reservoirs for low-waste, high-capacity drug loading.

Cade B Fox, Cameron L Nemeth, Rachel W Chevalier, Joshua Cantlon, Derek B Bogdanoff, Jeff C Hsiao, Tejal A Desai

Abstract read
In one paragraph

Article in Bioengineering & translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Orally ingestible medical devices for gut engineering.Advanced drug delivery reviews · 2020
    Review
  10. Editorial: The launch phase ofBioengineering & translational medicine · 2019
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cade B FoxDept. of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158.
Cameron L NemethUC Berkeley and UCSF Graduate Program in Bioengineering, UCSF Mission Bay Campus, San Francisco, CA 94158.
Rachel W ChevalierDept. of Pediatrics, Division of Pediatric Gastroenterology, School of Medicine, University of California, San Francisco, CA 94158.
Joshua CantlonScienion AG, Volmerstr. 7a, 12489 Berlin, Germany.
Derek B BogdanoffCenter for Advanced Technology, University of California, San Francisco, CA, 94158.
Jeff C HsiaoDept. of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158.
Tejal A DesaiDept. of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158.

Funding

UCSF/UCB Joint Graduate Group in BIoengineeringT32GM008155 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DESAI, TEJAL A. · 1985 to 2020
$12.2M
TRAINING PROGRAM IN PEDIATRIC GASTROENTEROLOGY/NUTRITIONT32DK007762 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI James Bayrer · 1998 to 2026
$7.3M
PHARMACEUTICAL SCIENCES AND PHARMACOGENOMICST32GM007175 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, KROETZ, DEANNA L · 1985 to 2021
$7.1M
Mechanisms of nanostructure-enhanced transepithelial drug deliveryR01EB018842 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DESAI, TEJAL A. · 2014 to 2017
$1.4M
NIBIB NIH HHS R01 EB018842NIDDK NIH HHS T32 DK007762NIGMS NIH HHS T32 GM007175NIGMS NIH HHS T32 GM008155
6 · The paper itself

Abstract

Oral delivery of therapeutics is the preferred route for systemic drug administration due to ease of access and improved patient compliance. However, many therapeutics suffer from low oral bioavailability due to low pH and enzymatic conditions, poor cellular permeability, and low residence time. Microfabrication techniques have been used to create planar, asymmetric microdevices for oral drug delivery to address these limitations. The geometry of these microdevices facilitates prolonged drug exposure with unidirectional release of drug toward gastrointestinal epithelium. While these devices have significantly enhanced drug permeability

Indexed as

drug Deliveryinkjet printinginsulinmicrodevicesnanobiotechnologytopotecan

Identifiers

PMID28503662
PMCPMC5426811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.