ArticleChild neurology open
Newly Identified Characteristics and Suggestions for Diagnosis and Treatment of Diffuse Leptomeningeal Glioneuronal/Neuroepithelial Tumors: A Case Report and Review of the Literature.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Clinical progression, pathological characteristics, and radiological findings in children with diffuse leptomeningeal glioneuronal tumors: A systematic review.Frontiers in oncology · 2022Pooled it
- From Diagnosis Delay to Targeted Therapy: A Retrospective Study of Pediatric DLGNT with a Comprehensive Literature Review.Cancers · 2026Article
- Diagnostic challenges of diffuse leptomeningeal glioneuronal tumor in an adult female: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Diffuse Leptomeningeal Glioneuronal Tumor: First Description of Metastasis to the Lung and Bone Marrow.Cureus · 2023Article
- Diffuse Leptomeningeal Glioneuronal Tumor with FGFR1 Mutation in a 29-Year-Old Male.Journal of the Korean Society of Radiology · 2023Article
- Rare Neuronal, Glial and Glioneuronal Tumours in Adults.Cancers · 2023Review
- Rapidly progressive diffuse leptomeningeal glioneuronal tumor in an adult female: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- Calcifications in diffuse leptomeningeal glioneuronal tumors: a case series.Quantitative imaging in medicine and surgery · 2022Article
- Diffuse leptomeningeal glioneuronal tumor without KIAA1549-BRAF fusion and 1p detection: a case report and review of literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Review
- Diffuse Leptomeningeal Glioneuronal Tumour with 9-Year Follow-Up: Case Report and Review of the Literature.Diagnostics (Basel, Switzerland) · 2022Article
- Atypical and aggressive diffuse leptomeningeal glioneuronal tumor in a young adult: A case report and review of the literature.Surgical neurology international · 2022Article
- Diffuse leptomeningeal glioneuronal tumour: where to biopsy? Case report and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Review
- Case Report: Unusual High-Grade Diffuse Leptomeningeal Glioneuronal Tumor Mimicking Tuberculous Meningitis in a Child From an Endemic Region.Frontiers in pediatrics · 2021Article
- Diffuse Leptomeningeal Glioneuronal Tumor of Childhood.AJNR. American journal of neuroradiology · 2020Article
- Diffuse leptomeningeal glioneuronal tumour (DLGNT) with hydrocephalus as an initial symptom: a case-based update.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Review
- A germline variant of TP53 in paediatric diffuse leptomeningeal glioneuronal tumour.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- Diffuse leptomeningeal glioneuronal tumor (DLGNT) mimicking Whipple's disease: a case report and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Review
- Clinical and molecular features of disseminated pediatric low-grade glioma and glioneuronal tumors: a systematic review and survival analysis.Neuro-oncology advancesArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diffuse leptomeningeal glioneuronal tumor is unique for communicating hydrocephalus, diffuse leptomeningeal enhancement, cystic changes, absence of tumor cells in cerebral spinal fluid, and a cell population of both glial and neuronal copositivity. It has likely been misdiagnosed as mixed glioneuronal tumors, oligodendrogliomas, and neuroepithelial tumors. Children with signs of this tumor are often worked up for infection, rheumatologic disease, or disseminated primary malignancy, resulting in unnecessary testing and treatment. We describe a 14-year-old female with recurrent headaches, hydrocephalus, and diffuse leptomeningeal enhancement discovered to be neoplastic 1 year after initial presentation, owing to extensive and unrevealing infectious and immunologic workups. Biopsies revealed atypical cells with markers of both glial and neuronal cells, positivity for OLIG-2, and focal p53 positivity. Great response was seen with temozolomide and craniospinal irradiation. Additionally, we postulate additional diagnostic indicators that may aid in earlier diagnosis and treatment decisions.
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