ArticleChild neurology open
Spontaneous Malignant Transformation of a Pilocytic Astrocytoma of Cerebellum: Case Report.
Article in Child neurology open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Unusual localization of pilocytic astrocytoma at the foramen of Monro mimicking a colloid cyst: a case report and literature review.Frontiers in oncology · 2025Article
- Pathological perspectives in pilocytic astrocytomas: Extent of resection as the sole critical factor for recurrence-free survival, and the challenge of evaluating conclusions derived from limited data.Free neuropathology · 2023Article
- Primary intramedullary spinal cord pilocytic astrocytoma with anaplasia in an adult: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
- Analysis of Clinical Characteristics and Risk Factors of Postoperative Recurrence and Malignant Transformation of Low-Grade Glioma.Journal of oncology · 2022Article
- The utilization of sodium fluorescein in pediatric brain stem gliomas: a case report and review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Review
- Recurrent adult pilocytic astrocytoma presenting with intraventricular and leptomeningeal spread.Surgical neurology international · 2021Article
- Clinical characteristics and prognostic factors of adult patients with pilocytic astrocytoma.Journal of neuro-oncology · 2020Article
- Diagnostic accuracy of diffusion weighted imaging for differentiation of supratentorial pilocytic astrocytoma and pleomorphic xanthoastrocytoma.Neuroradiology · 2018Article
- Exploiting molecular biology for diagnosis and targeted management of pediatric low-grade gliomas.Future oncology (London, England) · 2016Review
- Spinal high-grade astrocytoma with piloid features arising in a patient with molecularly confirmed cerebellar pilocytic astrocytoma.Neuro-oncology advancesArticle
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pilocytic astrocytoma is a slowly growing neoplasia that represents the most frequent cerebral tumor in pediatric age. Malignant transformation is rare and it is usually related to previous radiotherapy. The authors describe a case of a spontaneous malignant transformation of a pilocytic astrocytoma. A 3-year-old boy was diagnosed with a cerebellar hemisphere tumor. He was submitted to a complete excision of the lesion, and histological findings were consistent with pilocytic astrocytoma. It was negative for p53. Twelve years later he presented with a local recurrence. Histopathological diagnosis was glioblastoma and it was positive for p53. Death from disease progression occurred 16 months after the diagnosis of glioblastoma. This case suggests that patients with pilocytic astrocytoma need closer follow-up and further genotypic studies in order to provide clues to clinical behavior. Such understanding can allow us to stratify treatment accordingly and to proceed to more aggressive treatment when necessary.
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