ArticleInternational journal of ophthalmology2017
Expression and role of specificity protein 1 in the sclera remodeling of experimental myopia in guinea pigs.
Article in International journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- The mClinical epigenetics · 2026Article
- Macular cone cell mosaic metrics in myopia: severity evaluation and diagnostic efficiency using adaptive optics fundus camera.Eye (London, England) · 2026Article
- Canonical and emerging regulatory mechanisms of tissue remodeling: shared principles across organs and therapeutic opportunities.Frontiers in immunology · 2026Review
- MiR-204-5p may regulate oxidative stress in myopia.Scientific reports · 2024Article
- Expression and role of specificity protein 1 and collagen I in recurrent pterygial tissues.International journal of ophthalmology · 2021Article
- Association of Myopia and Genetic Variants ofFrontiers in cell and developmental biology · 2021Article
- Dynamic changes of periostin and collagen I in the sclera during progressive myopia in guinea pigs.Arquivos brasileiros de oftalmologia · 2020Article
- Epigenetically dysregulated genes and pathways implicated in the pathogenesis of non-syndromic high myopia.Scientific reports · 2019Article
- Dynamic changes of activator protein 1 and collagen I expression in the sclera of myopia guinea pigs.International journal of ophthalmology · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the expression of collagen I and transcription factor specificity protein 1 (Sp1), a transforming growth factor-β1 (TGF-β1) downstream target, and reveal the impact of the TGF-β1-Sp1 signaling pathway on collagen remodeling in myopic sclera.
methodsSeventy-five 1-week-old guinea pigs were randomly divided into normal control, form deprivation myopia (FDM), and self-control groups. FDM was induced for different times using coverage with translucent latex balloons and FDM recovery was performed for 1wk after 4wk treatment; then, changes in refractive power and axial length were measured. Immunohistochemistry and reverse transcription-polymerase chain reaction were used to evaluate dynamic changes in collagen I and Sp1 expression in the sclera of guinea pigs with emmetropia and experimental myopia, and the relationship between collagen I and Sp1 levels was analyzed.
resultsIn the FDM group, the refractive power was gradually changed (from 2.09±0.30 D at week 0 to -1.23±0.69 D, -4.17±0.59 D, -7.07±0.56 D, and -4.30±0.58 D at weeks 2, 4, 6, and 1wk after 4wk, respectively;
conclusionOur data indicate that transcription factor Sp1 may be involved in the regulation of type I collagen synthesis/degradation during myopic sclera remodeling, suggesting that TGF-β1 signaling plays a role in the development and progression of myopia.
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