Evidence map›Paper›PMID 28503403›Full record

ArticleAllergo journal international2017

Diagnostics in Hymenoptera venom allergy: current concepts and developments with special focus on molecular allergy diagnostics.

Thilo Jakob, David Rafei-Shamsabadi, Edzard Spillner, Sabine Müller

Open access · hybridAbstract read
In one paragraph

Article in Allergo journal international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
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  5. Editorial: venom collection.Scientific reports · 2025
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  19. A WAO - ARIA - GAThe World Allergy Organization journal · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Thilo JakobDepartment of Dermatology and Venerology, Medical Center - University of Freiburg, Hauptstraße 7, 79104 Freiburg, Germany.
David Rafei-ShamsabadiDepartment of Dermatology and Venerology, Medical Center - University of Freiburg, Hauptstraße 7, 79104 Freiburg, Germany.
Edzard SpillnerImmunological Engineering, Department of Engineering, Aarhus University, Aarhus, Denmark.
Sabine MüllerDepartment of Dermatology and Venerology, Medical Center - University of Freiburg, Hauptstraße 7, 79104 Freiburg, Germany.
Aarhus University · DKPhilipps University of Marburg · DEUniversity Medical Center Freiburg · DEUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe high rate of asymptomatic sensitization to Hymenoptera venom, difficulty in correctly identifying Hymenoptera and loss of sensitization over time make an accurate diagnosis of Hymenoptera venom allergy challenging. Although routine diagnostic tests encompassing skin tests and the detection of venom-specific IgE antibodies with whole venom preparations are reliable, they offer insufficient precision in the case of double sensitized patients or in those with a history of sting anaphylaxis, in whom sensitization cannot be proven or only to the presumably wrong venom.

methodsSystematic literature research and review of current concepts of diagnostic testing in Hymenoptera venom allergy. RESULTS AND DISCUSSION: Improvements in diagnostic accuracy over recent years have mainly been due to the increasing use of molecular allergy diagnostics. Detection of specific IgE antibodies to marker and cross-reactive venom allergens improves the discrimination between genuine sensitization and cross-reactivity, and this provides a better rationale for prescribing venom immunotherapy. The basophil activation test has also increased diagnostic accuracy by reducing the number of Hymenoptera venom sensitizations overlooked with routine tests. This paper reviews current concepts of diagnostic testing in Hymenoptera venom allergy and suggests fields for further development.

Indexed as

Basophil activation testcross-reactive carbohydrate determinantsDiagnostic algorithmRecombinant allergensSkin test

Identifiers

PMID28503403
PMCPMC5406443
OpenAlexW2606973690

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.