ArticlePeerJ2017
Network science meets respiratory medicine for OSAS phenotyping and severity prediction.
Article in PeerJ, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed.
- Onco-Hem Connectome-Network-Based Phenotyping of Polypharmacy and Drug-Drug Interactions in Onco-Hematological Inpatients.Pharmaceutics · 2026Article
- Knowledge, Beliefs and Preventive Practices Regarding Osteoporosis: A Cross-Sectional Study in Community Pharmacies in Tunis.Nutrients · 2025Article
- The Role of Oxidative Stress and the Potential Therapeutic Benefits ofAntioxidants (Basel, Switzerland) · 2024Review
- Fractional Dynamics Foster Deep Learning of COPD Stage Prediction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- COVID-19 Phenotypes and Comorbidity: A Data-Driven, Pattern Recognition Approach Using National Representative Data from the United States.International journal of environmental research and public health · 2022Article
- Obstructive Sleep Apnea Syndrome Comorbidity Phenotypes in Primary Health Care Patients in Northern Greece.Healthcare (Basel, Switzerland) · 2022Article
- Evaluation of Obstructive Sleep Apnea Phenotypes Treatment Effectiveness.Medicina (Kaunas, Lithuania) · 2021Article
- Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine.Diagnostics (Basel, Switzerland) · 2021Article
- An Update on Obstructive Sleep Apnea for Atherosclerosis: Mechanism, Diagnosis, and Treatment.Frontiers in cardiovascular medicine · 2021Review
- Sex Differences in the Physiological Network of Healthy Young Subjects.Frontiers in physiology · 2021Article
- Gender Phenotyping of Patients with Obstructive Sleep Apnea Syndrome Using a Network Science Approach.Journal of clinical medicine · 2020Article
- HIF-1α as a Mediator of Insulin Resistance, T2DM, and Its Complications: Potential Links With Obstructive Sleep Apnea.Frontiers in physiology · 2020Review
- Physiological Network From Anthropometric and Blood Test Biomarkers.Frontiers in physiology · 2020Article
- Particularities of Older Patients with Obstructive Sleep Apnea and Heart Failure with Mid-Range Ejection Fraction.Medicina (Kaunas, Lithuania) · 2019Article
- Sleep Study and Oximetry Parameters for Predicting Postoperative Complications in Patients With OSA.Chest · 2019Review
- Correlation between coronary artery disease and obstructive sleep apnea syndrome and analysis of risk factors.Experimental and therapeutic medicine · 2018Article
- SAS score: Targeting high-specificity for efficient population-wide monitoring of obstructive sleep apnea.PloS one · 2018Article
- Personalised medicine in sleep respiratory disorders: focus on obstructive sleep apnoea diagnosis and treatment.European respiratory review : an official journal of the European Respiratory Society · 2017Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obstructive sleep apnea syndrome (OSAS) is a common clinical condition. The way that OSAS risk factors associate and converge is not a random process. As such, defining OSAS phenotypes fosters personalized patient management and population screening. In this paper, we present a network-based observational, retrospective study on a cohort of 1,371 consecutive OSAS patients and 611 non-OSAS control patients in order to explore the risk factor associations and their correlation with OSAS comorbidities. To this end, we construct the Apnea Patients Network (APN) using patient compatibility relationships according to six objective parameters: age, gender, body mass index (BMI), blood pressure (BP), neck circumference (NC) and the Epworth sleepiness score (ESS). By running targeted network clustering algorithms, we identify eight patient phenotypes and corroborate them with the co-morbidity types. Also, by employing machine learning on the uncovered phenotypes, we derive a classification tree and introduce a computational framework which render the Sleep Apnea Syndrome Score (SAS
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.