ReviewTremor and other hyperkinetic movements (New York, N.Y.)2017
Focused Ultrasound for Essential Tremor: Review of the Evidence and Discussion of Current Hurdles.
Review in Tremor and other hyperkinetic movements (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07599592 (Open Label Study for the Use of Low Intensity Focused Ultrasound for Essential Tremor), which is not on this map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Open Label Study for the Use of Low Intensity Focused Ultrasound for Essential Tremor
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Enhancing precision in MRgFUS for tremor treatment: a systematic review of tractography-based VIM targeting approaches.Neurosurgical review · 2025Pooled it
- Comparative study of HIFU partial gland ablation and robot-assisted radical prostatectomy for localized prostate cancer: an evidence-based approach.Journal of robotic surgery · 2024Pooled it
- Magnetic Resonance-Guided Focused Ultrasound Neurosurgery for Essential Tremor: A Health Technology Assessment.Ontario health technology assessment series · 2018Pooled it
- Therapeutic potential of ultrasound for spinal cord injury.Neural regeneration research · 2026Article
- From competition to complementarity: narrative review of laser interstitial thermal therapy, focused ultrasound, and radiofrequency ablation in minimally invasive neurosurgery.Annals of medicine and surgery (2012) · 2026Review
- Ultrasonic modulation of brain glymphatic transport: from observations to theranostic applications.Cancer drug resistance (Alhambra, Calif.) · 2026Review
- From Ablation to Neuromodulation Platform: The Evolving Role of Magnetic Resonance-Guided Focused Ultrasound in Functional Neurosurgery.Journal of clinical neurology (Seoul, Korea) · 2026Review
- Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and Community Resource.medRxiv : the preprint server for health sciences · 2025Article
- Post-thalamotomy Changes Mimicking Cavernous Malformations on MRI: A Case Report of a Historical Surgical Treatment.Cureus · 2025Article
- Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature.Communications biology · 2025Article
- MR-guided focused ultrasound thalamotomy modulates cerebello-thalamo-cortical tremor network in essential tremor patients.Frontiers in neurology · 2025Article
- A Pilot Study of AI-Controlled Transcutaneous Peripheral Nerve Stimulation for Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Anesthesia Management for High-Intensity Focused Ultrasound (HIFU) Thalamotomy for Movement Disorders: A Case Series from the National University Hospital of the Philippines.Acta medica Philippina · 2025Article
- Epidemiology and treatment patterns of essential tremor: a retrospective cohort analysis in Germany.Frontiers in neurology · 2025Article
- Quantitative Tractography-Based Evaluations in Essential Tremor Patients after MRgFUS Thalamotomy.Movement disorders clinical practice · 2024Article
- Magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor in a patient with von Willebrand disease: perioperative optimization for patients with coagulopathies. Illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Dynamic functional changes upon thalamotomy in essential tremor depend on baseline brain morphometry.Scientific reports · 2024Article
- Hydrogels in wearable neural interfaces.Med-X · 2024Review
- Controlled Hyperthermia With High-Intensity Focused Ultrasound and Ultrasound Contrast Agent Microbubbles in Porcine Liver.Ultrasound in medicine & biology · 2023Article
- Top-down control of human motor thalamic neuronal activity during the auditory oddball task.NPJ Parkinson's disease · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile there is no breakthrough progress in the medical treatment of essential tremor (ET), in the past decades several remarkable achievements happened in the surgical field, such as radiofrequency thalamotomy, thalamic deep brain stimulation, and gamma knife thalamotomy. The most recent advance in this area is magnetic resonance-guided focused ultrasound (MRgFUS).
methodsThe purpose of this review is to discuss the new developments and trials of MRgFUS in the treatment of ET and other tremor disorders.
resultsMRgFUS is an incisionless surgery performed without anesthesia and ionizing radiation (no risk of cumulative dose and delayed side effects). Studies have shown the safety and effectiveness of unilateral MRgFUS-thalamotomy in the treatment of ET. It has been successfully used in a few patients with Parkinson's disease-related tremor, and in fewer patients with fragile X-associated tremor/ataxia syndrome. The safety and long-term effects of the procedure are still unclear, as temporary and permanent adverse events have been reported as well as recurrence of tremor. DISCUSSION: MRgFUS is a promising new surgical approach with a number of unknowns and unsolved issues. It represents a valuable option particularly for patients who refused or could not be candidates for other procedures, deep brain stimulation in particular.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.