Evidence map›Paper›PMID 28503156›Full record

ReviewFrontiers in psychiatry2017

Effects of Antipsychotic Administration on Brain Glutamate in Schizophrenia: A Systematic Review of Longitudinal

Alice Egerton, Akarmi Bhachu, Kate Merritt, Grant McQueen, Agata Szulc, Philip McGuire

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 7 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 7 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Pooled it
  2. Glutamatergic Modulation of Brain Function in Psychosis: A Systematic Review of Neuroimaging Studies.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025
    Pooled it
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  8. Does a monoclonal antibody targeting immune cells affect glutamatergic level in schizophrenia? A multimodal PET/MRS brain imaging study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  17. Glutamatergic basis of antipsychotic response in first-episode psychosis: a dual voxel study of the anterior cingulate cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Alice EgertonDepartment of Psychosis Studies, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Akarmi BhachuDepartment of Psychosis Studies, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Kate MerrittDepartment of Psychosis Studies, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Grant McQueenDepartment of Psychosis Studies, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Agata SzulcDepartment of Psychiatry, Medical University of Warsaw, Warsaw, Poland.
Philip McGuireDepartment of Psychosis Studies, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
King's College London · GBMedical University of Warsaw · PL

Funding

Medical Research Council MR/L003988/1Medical Research Council MR/N026063/1
6 · The paper itself

Abstract

Schizophrenia is associated with brain glutamate dysfunction, but it is currently unclear whether antipsychotic administration can reduce the extent of glutamatergic abnormality. We conducted a systematic review of proton magnetic resonance spectroscopy (

Indexed as

antipsychoticsglutamatesmagnetic resonance spectroscopyschizophreniatreatment response

Identifiers

PMID28503156
PMCPMC5408014
OpenAlexW2609221543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.