ReviewCurrent neuropharmacology2017
Diagnosis and Treatment of Cyclothymia: The "Primacy" of Temperament.
Review in Current neuropharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Emotional Dysregulation in Children and Adolescents With Psychiatric Disorders. A Narrative Review.Frontiers in psychiatry · 2021Pooled it
- Cyclothymic-hypersensitive temperament in early adolescence: Longitudinal measurement invariance and associations with psychopathology over time.JCPP advances · 2026Article
- On Churchill's black dog, Barzun's bicycle, and cartoon bears: living within the bipolar temperament.International journal of bipolar disorders · 2026Review
- Normative scores and clinical cut-offs of the Cyclothymic-Hypersensitive Temperament Questionnaire in adolescence.JCPP advances · 2026Article
- The Regulatory Potential of Long Non-Coding RNAs in Bipolar Disorder.International journal of molecular sciences · 2026Review
- Insomnia and the question of psychomotor agitation as a possible cause for zolpidem abuse.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2026Article
- Emotional Dysregulation and Temperament in Adolescents with Acute Psychiatric Conditions: Gender Differences and the Role of Psychiatric Diagnosis.Journal of clinical medicine · 2026Article
- Effectiveness of Pharmacological Treatments for Adult ADHD on Psychiatric Comorbidity: A Systematic Review.Journal of clinical medicine · 2025Review
- New-onset Kleine-Levin syndrome following COVID-19 infection: A case report.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Exploration of Nursing Care for Individuals With Bipolar Disorder in a Manic Episode: A Qualitative Study.Cureus · 2024Article
- Novel Advancements in COVID-19 and Neuroscience.Journal of personalized medicine · 2024Article
- The role of affective temperaments in self-care and medication adherence among individuals with bipolar disorder: a moderation analysis.Frontiers in psychiatry · 2024Article
- Persistent Non-Suicidal Self-Injury and Suicidality in Referred Adolescents: A Longitudinal Study Exploring the Role of Cyclothymic Temperament.Brain sciences · 2023Article
- Comorbidities in Youth with Bipolar Disorder: Clinical Features and Pharmacological Management.Current neuropharmacology · 2023Review
- Triple Diagnosis of Attention-Deficit/Hyperactivity Disorder with Coexisting Bipolar and Alcohol Use Disorders: Clinical Aspects and Pharmacological Treatments.Current neuropharmacology · 2023Review
- Affective temperaments of Lebanese patients with schizophrenia: comparison by gender and severity of psychosis.BMC research notes · 2021Article
- Relationships of affective temperament ratings to diagnosis and morbidity measures in major affective disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2021Article
- Comparison of Emotional Dysregulation Features in Cyclothymia and Adult ADHD.Medicina (Kaunas, Lithuania) · 2021Article
- Affective Temperaments and Clinical Course of Bipolar Disorder: An Exploratory Study of Differences among Patients with and without a History of Violent Suicide Attempts.Medicina (Kaunas, Lithuania) · 2019Article
- Opposing patterns of neuronal variability in the sensorimotor network mediate cyclothymic and depressive temperaments.Human brain mapping · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundContrary to DSM-5 definition based on recurrence of low grade hypomanic and depressive symptoms, cyclothymia is better defined in a neurodevelopmental perspective as an exaggeration of cyclothymic temperament. Emotional dysregulation with extreme mood instability and reactivity is the core features of the complex symptomatology.
methodIn the present article, we critically reviewed the literature on the diagnosis and treatment of cyclothymia, focusing on the temperamental and neurodevelopmental perspectives.
resultsCurrent epidemiological and clinical research showed the high prevalence and the validity of cyclothymia as a distinct form of bipolarity, frequently associated with multiple comorbidities with anxiety, impulse control, substance use, and so called "personality" disorders. Many patients receive correct diagnosis and treatments after many years of illness, when the superposition of complications reduces the possibility of complete remission. A therapeutic model combining the focus on symptomatic presentations with a temperamental perspective seems to represent an effective approach for cyclothymic patients with complex clinical presentations.
conclusionCyclothymic mood instability is an understudied issue despite the evidence of its clinical relevance. Unresolved issues concern its diagnostic delimitation and the possible relationships with emotional dysregulation observed in other neurodevelopmental disorders. We need to confirm the specificity of the disorder and to improve its recognition in early phase of the life, especially in youth. Early recognition means avoiding unnecessary complications and establishing specific treatments and clinical management since the beginning.
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