Observational studyCurrent neuropharmacology2017
The Role of Electroconvulsive Therapy (ECT) in Bipolar Disorder: Effectiveness in 522 Patients with Bipolar Depression, Mixed-state, Mania and Catatonic Features.
Observational study in Current neuropharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05891639 (Investigating Factors Affecting Clinical Trial Participation Rates in Patients With Bipolar Disorder), which is not on this map. Cited by 53 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating Factors Affecting Clinical Trial Participation Rates in Patients With Bipolar Disorder
Who cites it
53 citing papers in PubMed, 4 syntheses or guidelines pooled it, 163 citations in OpenAlex.
- Safety of electroconvulsive therapy (ECT) in pregnancy: a systematic review of case reports and case series.Archives of women's mental health · 2024Pooled it
- Evidence-based consensus guidelines for the management of catatonia: Recommendations from the British Association for Psychopharmacology.Journal of psychopharmacology (Oxford, England) · 2023Guideline
- The CINP Guidelines on the Definition and Evidence-Based Interventions for Treatment-Resistant Bipolar Disorder.The international journal of neuropsychopharmacology · 2020Pooled it
- Face and predictive validity of the ClockΔ19 mouse as an animal model for bipolar disorder: a systematic review.Molecular psychiatry · 2018Pooled it
- Magnetic seizure therapy is efficacious and well tolerated for treatment-resistant bipolar depression: an open-label clinical trialJournal of psychiatry & neuroscience : JPN · 2020Trial
- Ultra-Rapid Cycling Bipolar Disorder: A Case Report.Cureus · 2026Article
- Electroconvulsive therapy and autobiographical memory.Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law · 2026Article
- Clinical practice guidelines for the management of bipolar disorder: 2025 update.Indian journal of psychiatry · 2026Article
- Progressive muscle relaxation to reduce anxiety before electroconvulsive therapy (ECT).BMC nursing · 2025Article
- Electroconvulsive Therapy: A Scotland-Wide Naturalistic Study of 4826 Treatment Episodes.Biological psychiatry global open science · 2025Article
- Outpatient Management of Bipolar Disorder in Older Adults.Current psychiatry reports · 2025Review
- Early career psychiatrists' perceptions of and training experience in electroconvulsive therapy: A cross-sectional survey across Europe.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Knowledge, attitudes, and willingness of bipolar disorder patients toward electroconvulsive therapy: a cross-sectional study.Frontiers in public health · 2025Article
- The impact of video-based education on the fear and anxiety of patients with bipolar disorders as candidates for electroconvulsive therapy: A clinical trial study.Journal of education and health promotion · 2025Article
- Immune-inflammatory, neuroplastic, and epigenetic effects of electroconvulsive therapy in mood disorders: an overview of recent studies.Frontiers in psychiatry · 2025Review
- Achieving Response With Bolus Dosing of Valproate in Electroconvulsive Therapy (ECT)-Induced Mania: A Case Report.Cureus · 2025Article
- Article
- Clinical and sociodemographic characteristics associated with relapse following electroconvulsive therapy for bipolar disorder.Bipolar disorders · 2024Article
- Experience of using electroconvulsive therapy for bipolar disorder: A retrospective study from North India.Indian journal of psychiatry · 2024Article
- Neuromodulation of Eating Disorders: A Review of Underlying Neural Network Activity and Neuromodulatory Treatments.Brain sciences · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe evaluated the effectiveness of Electroconvulsive Therapy (ECT) in the treatment of Bipolar Disorder (BD) in a large sample of bipolar patients with drug resistant depression, mania, mixed state and catatonic features.
method522 consecutive patients with DSM-IV-TR BD were evaluated prior to and after the ECT course. Responders and nonresponders were compared in subsamples of depressed and mixed patients. Descriptive analyses were reported for patients with mania and with catatonic features.
resultsOf the original sample only 22 patients were excluded for the occurrence of side effects or consent withdrawal. After the ECT course, 344 (68.8%) patients were considered responders (final CGIi score ≤2) and 156 (31.2%) nonresponders. Response rates were respectively 68.1% for BD depression, 72.9% for mixed state, 75% for mania and 80.8% for catatonic features. Length of current episode and global severity of the illness were the only statistically significant predictors of nonresponse.
conclusionECT resulted to be an effective and safe treatment for all the phases of severe and drug-resistant BD. Positive response was observed in approximately two-thirds of the cases and in 80% of the catatonic patients. The duration of the current episode was the major predictor of nonresponse. The risk of ECT-induced mania is virtually absent and mood destabilization very unlikely. Our results clearly indicate that current algorithms for the treatment of depressive, mixed, manic and catatonic states should be modified and, at least for the most severe patients, ECT should not be considered as a "last resort".
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.