ReviewCurrent neuropharmacology2017
Depression and Mania in Bipolar Disorder.
Review in Current neuropharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04222816 (Effect of Regulated Add -on Sodium Chloride Intake on Stabilization of Serum Lithium Concentration in Bipolar Disorder), which is not on this map. Cited by 91 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Regulated Add -on Sodium Chloride Intake on Stabilization of Serum Lithium Concentration in Bipolar Disorder: A Randomized Controlled Trial
Who cites it
91 citing papers in PubMed, 4 syntheses or guidelines pooled it, 171 citations in OpenAlex.
- Efficacy and tolerability of FDA-approved atypical antipsychotics for the treatment of bipolar depression: a systematic review and network meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2024Pooled it
- Risk factors for relapse or recurrence in women with bipolar disorder and recurrent major depressive disorder in the perinatal period: a systematic review.Archives of women's mental health · 2023Pooled it
- Cerebral glucose metabolism in bipolar disorder: A voxel-based meta-analysis of positron emission tomography studies.Brain and behavior · 2021Pooled it
- Effectiveness of Sleep Deprivation in Treating Acute Bipolar Depression as Augmentation Strategy: A Systematic Review and Meta-Analysis.Frontiers in psychiatry · 2020Pooled it
- Medicine Use Preceding Fatal Poisonings Among Individuals With Bipolar Disorder.Basic & clinical pharmacology & toxicology · 2026Article
- Comparative Analysis of the Burden of Bipolar Disorder Among Individuals Aged 15-49 Years in China and Globally, 1990-2021: An Ecological Trend Analysis Based on GBD 2021.Health science reports · 2026Article
- GBR 12909, a Selective Dopamine Transporter Inhibitor, Differentially Modulates Affective, Exploratory and Cognitive Domains in Zebrafish.The European journal of neuroscience · 2026Article
- A 3-Month Follow-Up Pilot Study on Accelerated Intermittent Theta Burst Stimulation for Bipolar Depression.Bipolar disorders · 2026Article
- Adaptation of the Barcelona Bipolar Eating Disorder Scale to Turkish and investigation of its validity and reliability.Journal of eating disorders · 2026Article
- Global burden and trends of depression among women of childbearing age, 1990-2021.Public health in practice (Oxford, England) · 2026Article
- Exploring the Association Between Mental Disorders and Various Arrhythmias via Mendelian Randomization Methods.Genes, brain, and behavior · 2026Article
- Alteration of brain activity in adolescent bipolar disorder: impact of positive emotional stimuli on attentional process.European archives of psychiatry and clinical neuroscience · 2026Article
- Pharmacological Management, Safety, and Outcomes in Bipolar Disorder: An Integrated Narrative Review of Clinical and Translational Evidence.Neuropsychopharmacology reports · 2026Review
- The Regulatory Potential of Long Non-Coding RNAs in Bipolar Disorder.International journal of molecular sciences · 2026Review
- Parallels between bipolar disorder and ATP1A3-related diseases: a window into the investigation of lithium for alternating hemiplegia of childhood.Orphanet journal of rare diseases · 2026Review
- Cognitive Impairment and Non-Invasive Neuromodulation Interventions in Bipolar Disorder: A Narrative Review of Current Status and Future Directions.Alpha psychiatry · 2026Review
- Findings on Impact of Circadian Genes and Bipolar Disorder: A Bibliometric Analysis From 1996 to 2024.Brain and behavior · 2026Article
- Incidence and characteristics of bipolar disorder in middle-aged adults: a prospective population-based study.International journal of bipolar disorders · 2026Article
- Multi-modal deep learning model for bipolar depression adolescents with verbal auditory hallucinations.Frontiers in psychiatry · 2026Article
- The aryl hydrocarbon receptor and kynurenine pathway: connecting inflammatory bowel disease and depression via the microbiota gut brain axis.Frontiers in neuroscience · 2026Review
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpisode duration, recurrence rates, and time spent in manic and depressive phases of bipolar disorder (BD) is not well defined for subtypes of the disorder.
methodsWe reviewed the course, timing, and duration of episodes of mania and depression among 1130 clinically treated DSM-IV-TR BD patients of various types, and compared duration and rates as well as total proportion of time in depressive versus manic episodes during 16.7 average years at risk.
resultsAs expected, episodes of depressions were much longer than manias, but episode-duration did not differ among BD diagnostic types: I, II, with mainly mixed-episodes (BD-Mx), or with psychotic features (BD-P). Recurrence rates (episodes/year) and proportion of time in depression and their ratios to mania were highest in BD-II and BD-Mx subjects, with more manias/year in psychotic and BD-I subjects. In most BD-subtypes, except with psychotic features, there was more time in depressive than manic morbidity, owing mainly to longer depressive than manic episodes. The proportion of time in depression was highest among those who followed a predominant DMI course, whereas total time in mania was greatest in BD with psychotic features and BD-I. and with an MDI course.
conclusionsSubtypes of BD patients differed little in episode-duration, which was consistently much longer for depression. The findings underscore the limited control of bipolar depression with available treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.